IMBB-Crete, GREECE-Postdoc position

Anastassios Economou Anastassios.Economou at dartmouth.edu
Tue Apr 30 12:33:35 EST 1996


INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY and DEPT. OF BIOLOGY,
UNIVERSITY OF CRETE, IRAKLIO-CRETE, GREECE

AVAILABLE POSITION: 
One postdoctoral fellow 
STARTING DATE : 
October 1996
RESEARCH PROJECT:
Molecular characterization of secretory protein translocation across
biological membranes using E.coli as a model system. E.coli preprotein
translocase,a complex membrane protein, has been purified and the
reaction has been fully reconstituted in vitro (Economou and Wickner,
1994 Cell 78:835-43; Economou et al., 1995 Cell, 83:1171-81). The
project will make use of molecular biology and biochemical techniques
to explore further  the energetics, catalytic mechanism and structure
of preprotein translocase. Structural studies of translocase subunits
will be carried out in collaboration with Prof. Michalis Kokkinidis
(IMBB Structural Biology group; for recent work see Athanasiadis et
al., 1994, Nature Struct Biol,1:469-75; Vlassi et al., 1994, Nature
Struct Biol, 1:706-16; Kokkinidis et al., 1993 Proteins 16:214-6) and
Dr. Stephen Cusack (EMBL-Grenoble; for recent work see Cusack S 1995,
Nature Struct Biol, 2:824-31; Baudin F et al., 1994 EMBO J, 13:3158-65;
Biou V et al, 1994 Science 263:1404-10)
DESIRED EXPERIENCE: 
Strong molecular biology and/or protein biochemistry skills. A
background in X-ray crystallography and computers/interactive modelling
systems is essential for the structure determination project. 
FUNDING:
Funding for the project is provided by European Union and Hellenic
Research Secretariat sources. 
OTHER INFO:
Active collaborations exist with several other European labs (as part
of EU-funded networks) and exchange visits to carry out experiments
using specialized equipment are encouraged. The work will be carried
out in the brand new Biology labs (Voutes Campus, outside Iraklio). The
official language of the lab is English.
CONTACT INFO:
Interested applicants should send a CV and three letters of
recommendation to:
Dr. Tassos Economou
IMBB-FORTH,
PO Box 1527 Iraklio,
Crete, GREECE

Tel:  +30-81-210 091
Fax: +30-81-230 469

For more details contact T.Economou at: aeconomou at nefeli.imbb.forth.gr
and M. Kokkindis at: kokkinidis at nefeli.imbb.forth.gr. More info on
research at the IMBB can be found in the Internet at:
http://www.imbb.forth.gr/ 




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