crystallography fall course at Cold Spring Harbor

David_Stewart stewart at
Mon Jun 10 09:26:19 EST 1996

October 10 - 23, 1996


William Furey, V.A. Medical Center, Pittsburgh
Gary Gilliland, Center for Advanced Research in Biotechnology
Alexander McPherson, University of California, Riverside
James Pflugrath, Molecular Structure Corporation

Crystallography and X-ray diffraction yield a wealth of structural 
information unobtainable through other methods.  This intensive 
laboratory/computational course will focus on the major techniques used 
to determine the three-dimensional structures of macromolecules.  It is 
designed for scientists with a working knowledge of protein structure 
and function, but who are new to macromolecular crystallography.  Topics 
that will be covered include crystallization (proteins, nucleic acids 
and complexes), crystal characterization, X-ray sources and optics, 
crystal freezing, data collection, data reduction, anomalous dispersion, 
multiple isomorphous replacement, phase determination, solvent, 
flattening, molecular replacement and averaging, electron density 
interpretation, structure refinement, molecular graphics, molecular 
dynamics and multi-dimensional NMR.  Participants will learn through 
extensive hands-on experiments where they will crystallize and determine 
a protein structure, along with lectures and informal discussions on the 
theory behind the techniques.

Information about our courses and meetings and how to apply for this
course, fees, scholarships, how to get to Cold Spring Harbor etc, is
all available at our web site

Meetings & Courses, Cold Spring Harbor Laboratory, Cold Spring Harbor, 
New York 11724-2213
General info at ** general enquiries: 
meetings at**Tel 516 367 8346**Fax 516 367 8845**

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