Homology modelling question

Simon M. Brocklehurst smb at bioch.ox.ac.uk
Mon May 20 07:39:54 EST 1996


Shoba.Ranganathan wrote:
> 
> Hi,
> 
> I'm looking for  references that state the minimum sequence identity
> required for homology modelling, and the percentage in the reference
> (in case I can't find the article).
> 
  You might want to consider using the term "comparative modelling", as opposed
to "homology modelling".  The reason for this is that the minimum sequence
identity that is "required" for useful 3-D prediction and modelling can be as
low as zero percent (or some other statistically insignificant 
similarity). Thus it is, in fact, possible to model the structure of a protein
based on the structure of an unrelated (or very distantly related) protein.  
  Check out the high quality structure prediction, which used a combination of
several state-of-the-art techniques, in:

->TI: THE PROTEIN FOLD OF THE VON-WILLEBRAND-FACTOR TYPE-A DOMAIN IS
      PREDICTED TO BE SIMILAR TO THE OPEN TWISTED BETA-SHEET FLANKED BY
      ALPHA-HELICES FOUND IN HUMAN RAS-P21
  AU: EDWARDS_YJK, PERKINS_SJ
  JN: FEBS LETTERS, 1995, Vol.358, No.3, pp.283-286

  -- Simon
_____________________________________________________________________________
|
|  ,_ o     Simon M. Brocklehurst,
| /  //\,   Oxford Centre for Molecular Sciences, Department of Biochemistry,
|   \>> |   University of Oxford, Oxford, UK.
|    \\,    E-mail: smb at bioch.ox.ac.uk | WWW: http://www.ocms.ox.ac.uk/~smb/ 
|____________________________________________________________________________




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