Shoba.Ranganathan wrote:
>> Hi,
>> I'm looking for references that state the minimum sequence identity
> required for homology modelling, and the percentage in the reference
> (in case I can't find the article).
> You might want to consider using the term "comparative modelling", as opposed
to "homology modelling". The reason for this is that the minimum sequence
identity that is "required" for useful 3-D prediction and modelling can be as
low as zero percent (or some other statistically insignificant
similarity). Thus it is, in fact, possible to model the structure of a protein
based on the structure of an unrelated (or very distantly related) protein.
Check out the high quality structure prediction, which used a combination of
several state-of-the-art techniques, in:
->TI: THE PROTEIN FOLD OF THE VON-WILLEBRAND-FACTOR TYPE-A DOMAIN IS
PREDICTED TO BE SIMILAR TO THE OPEN TWISTED BETA-SHEET FLANKED BY
ALPHA-HELICES FOUND IN HUMAN RAS-P21
AU: EDWARDS_YJK, PERKINS_SJ
JN: FEBS LETTERS, 1995, Vol.358, No.3, pp.283-286
-- Simon
_____________________________________________________________________________
|| ,_ o Simon M. Brocklehurst,
| / //\, Oxford Centre for Molecular Sciences, Department of Biochemistry,
| \>> | University of Oxford, Oxford, UK.
| \\, E-mail: smb at bioch.ox.ac.uk | WWW: http://www.ocms.ox.ac.uk/~smb/|____________________________________________________________________________
