catalysis in xtals

Cameron Dunn C.Dunn at bristol.ac.uk
Tue Nov 5 12:17:42 EST 1996


> Not asymmetric catalysis, but asymmetric binding... Anyway,
> a substrate-sized inhibitor was seen (crystallographically) to diffuse in
> and out of one subunit, but not the other, of a dimeric A.U. of LDH,
> because packing restraints held the latter subunit in the conformation
> preferred by the enzyme/substrate complex.

That makes no sense :(
I meant to say that the the crystal was grown as an enzyme/inhibitor complex,
and only the unrestrained subunit could change shape and release its inhibitor
(and re-bind it) while the restrained subunit could not release the inhibitor
in the first place !




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