Fredrick deMare wrote:
>> Hi there!
>> Does anyone know of a case where catalysis in crystals has been done on
> dimers, and a difference in reactivity between monomers has been seen?
Not asymmetric catalysis, but asymmetric binding... Anyway,
a substrate-sized inhibitor was seen (crystallographically) to diffuse in
and out of one subunit, but not the other, of a dimeric A.U. of LDH,
because packing restraints held the latter subunit in the conformation
preferred by the enzyme/substrate complex.
The report is in Phil.Trans.R.Soc.Lond.B (1991) 332 p177 and the pdb ID is 9ldb.
--
--------------------------------------------
| Cameron Dunn |
| Department of Biochemistry |
| Bristol University |
| Bristol BS8 1TD U.K. Tel 0117 9289708 |
--------------------------------------------
