Post-doc/Toronto/DNA replication/gene expression

Aled Edwards edwardsa at fhs.csu.McMaster.CA
Tue Nov 12 23:17:17 EST 1996

Post-doctoral opportunities in molecular biology and crystallography

        We are interested in uncovering the mechanisms that underlie the
initiation of DNA replication and the regulation of gene expression through
a combination of molecular biological and structural approaches.  Our
previous studies have included the structure and function of DNA
replication origin binding proteins [Bochkarev, A. et al. Cell, 83: 39-46,
(1995); Bochkarev, A. et al  Cell, 84: 791-800 (1996)]; single-stranded DNA
binding proteins (Bochkarev, A. et al. Nature, in press); and transcription
elongation factors [Wu, J. et al.  Proc. Nat. Acad. Sci. U.S.A.  93:
11552-11557 (1996); Morin, P. et al.  Proc. Nat. Acad. Sci. U.S.A. 93:
10604-10608  (1996)].  We have also been exploring the use of lipid-layers
to promote crystal growth [Edwards, A.M. et al.  Nature Struct. Biol.
1:195-197 (1994); Darst, S.A. and Edwards, A.M.  Curr. Opin. in Struct.
Biol. 5: 640-644, (1995);  Hemming, S.A. et al  J. Mol. Biol. 246: 308-316
(1995)]. We are interested in recruiting exceptional post-doctoral fellows
who have considerable experience in protein crystallography but who are
keenly interested in learning and applying molecular biological approaches
and techniques.  Applicants must have a Ph.D. or an M.D., fewer than two
years of postdoctoral experience and a demonstrated ability in research.
In July 1997, our two laboratories will be moving from McMaster University
to the University of Toronto which, together with its affiliated research
institutes, comprises one of the most active biomedical research
communities in North America. The University itself is located in the center 
of Toronto, a vibrant and exciting city in which to live.

If you are interested, please send your CV and names of three references 
by email to Edwardsa at

aled edwards                                    
assistant professor
institute for molecular biology and biotechnology
cancer research group, HSC-4H30
mcmaster university 
1200 main st. w.                 
hamilton, ontario               Tel: 1-905-525-9140 x22392
canada L8N 3Z5                  FAX: 1-905-546-9940

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