postdoctoral position available

Joseph Kraut joek at
Sat Feb 15 14:20:32 EST 1997

A postdoctoral position is available immediately for an
experienced protein crystallographer to continue and extend
our structure-function studies on human DNA polymerase beta
(see Biochemistry 35, pp. 12742-12787 (1996)).  In addition
to the structures described in the references, we already
have a newly solved crystal form of the enzyme complexed
DNA containing a single nucleotide gap and a bound dNTP.
Our immediate objective is further to investigate the
basis of the nucleotidyl transfer reaction, base selectivity
(fidelity) and the DNA translocation mechanism by varying
the precise composition of these crystals.  Other protein
structural projects are also underway, depending on our
ability to grow suitable crystals. We are seeking a person
with a high degree of initiative and a preference for
independent work.  Our research group is small, but well
equipped with its own area-detector diffractometer,
two SGI graphics computers and protein preparation
facilities. Not the least important consideration is that
La Jolla is an exceptionally stimulating scientific
with several neighboring protein crystallographic
and with the world's best weather.

Please send your CV and names of 2 references to:
   Prof. Joseph Kraut
   Department of Chemistry and Biochemistry
   University of California, San Diego
   La Jolla, CA 92093-0506

   e-mail: jkraut at
   phone: 619-534-3366
   fax: 619-822-0346

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