Postdoctoral Positions in
Structural Biology and Signal Transduction
Two postdoctoral positions are available to (1) study the structural
aspects of growth factor receptor activation and (2) develop inhibitors
of growth factor receptor activation. Our laboratory has developed novel
soluble molecules that mimic the active state of growth factor receptors.
These soluble receptor mimics are being used in crystallographic and
biochemical studies, and as targets to screen combinatorial libraries
for inhibitors of receptor activation.
Candidates must have research experience in either X-ray crystallography,
molecular biology, protein biochemistry or combinatorial chemistry.
Facilities include state-of-the-art laboratories for X-ray
cryocrystallography, large-scale bacterial cell growth, Sf9 insect cell
growth, tissue culture
and protein analysis. Instrumentation available for structural studies
include a MacScience 30 cm imaging plate detector, a Siemens 2K CCD
detector, two rotating anode X-ray generators equipped with cross-coupled
Gobel mirrors, a Micromass ion-spray mass spectrometer, SGI multiprocessor
computers and graphics workstations, and a Cray J90 supercomputer.
Applicants should send a CV, list of publications, statement of research
interests, and the names, addresses and telephone numbers of three
references to:
Dr. Stan Watowich
Sealy Center for Structural Biology
Department of Human Biological Chemistry & Genetics
University of Texas Medical Branch
Galveston, TX 77555-0645
U.S.A.
Phone: 409-747-4749
Fax: 409-747-4745
E-mail:watowich at bloch.utmb.edu
