ACA Summer Course

John P. Rose Ph.D. rose at bcl4.bmb.uga.edu
Thu Apr 30 06:27:43 EST 1998


Dear Colleague,

The seventh annual ACA Summer Course for Crystallographers will be a 12 day
course held from July 5 to July 16, 1998 at the University of Georgia, Athens
GA. Please pass this information on to whoever you feel would be interested.

This year the course will be expanded to include more time for macromolecular
crystallography. The first 8 days will be devoted to lectures and laboratory
sessions for basic crystallography. In the afternoon of day 9 the students will
give short presentations on the structures they worked on during the first part
of the course. In the evening of day 9 and continuing through day 12 there will
be lectures and laboratory sessions for macromolecular crystallography.

The basic crystallography part of the course will include lectures on the basic
mathematics and physics behind structural analysis, the methods of structure
solution, the refinement of atomic parameters and presentation and analysis of
the results of structure determination. The laboratory part of the course will
teach the students to select and mount crystals, determine unit cell dimensions
and collect data on modern diffractometers. They will learn to use modern
software to determine space groups and solve and refine structures and compare
the final structures with previously determined structures. Finally they will
use software to prepare plots and reports of their structures.

The macromolecular part of the course will include lectures on crystallization,
data collection strategies, determination of heavy atom sites, structure
solution by MIR, SIR, MAD, SAS and molecular replacement techniques, chain
tracing and structure model building. Lectures concerning refinement methods
and use of databases will also be included. The laboratory part of the course
will include demonstrations of the methods for crystallization of proteins, the
methods for phase calculations using MIR/SIR/MAD/SAS and the methods for model
building and refinement.

The University of Georgia (UGA) has equipment from all four major vendors
(Nonius and Bruker diffractometers in Chemistry and Rigaku, MarResearch and
Bruker area detectors in Biochemistry and Molecular Biology). The associated
computers and software are available in each of these departments.

The lecturers will be the two co-Directors: Prof. Bi-Cheng Wang (UGA) and Dr.
Robert A. Sparks (Consultant, Bruker Corp.), together with the faculty listed
below.  In addition, experienced laboratory instructors will be available in
each of the crystallography laboratories.

A revised set of lecture notes will be given to each student.

Tuition for the course will be $600. Admission will be limited to approximately
40 students. A number of tuition scholarships will be provided on a competitive
basis. The criteria for these awards are (1) expected benefits from the course,
(2) qualification and (3) motivation.

In addition, the International Union of Crystallography has provided funds to
allow a limited number of young scientists from the less-favored regions of the
Americas to attend the Summer Course.  The IUCr awards will be made based on
the above criteria and are intended to help cover travel and local expenses.
Students selected for the IUCr Awards will also receive tuition scholarships.

Accommodations have been reserved at UGA from the evening of July 4; the rate
for these air-conditioned rooms will be $30 per day single, or $19 per day
double occupancy. Student housing is only a short walk from where the lectures
will be given and from the laboratories with the X-ray equipment that will be
used.  There are several local hotels within walking distance to the both the
lecture hall and X-ray diffraction facilities.

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                  1998 ACA Summer Application Materials

                         DEADLINE June 10, 1998

Application forms and other material are available on the WEB.

                 URL: www.uga.edu/~biocryst/ACA98.html

Application material may also be obtained from:

                Dr. John Rose
                Department of Biochemistry & Molecular Biology
                University of Georgia
                Athens, GA 30602

                Telephone: (706) 542-1750
                FAX:       (706) 542-3077
                E-mail:    rose at bcl4.biochem.uga.edu (BCL4)

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                  1998 ACA Summer Course Lecturers

    Wally Cordes             University of Arkansas
    Bryan Craven             Indiana University, Pennsylvania
    Lawrence DeLucas         University of Alabama, Birmingham
    William Furey            VA Medical Center, Pittsburgh
    Herbert Hauptman         Hauptman-Woodward Medical Research Institute
    Leigh Ann Lipscomb       University of Georgia
    Zhi-Jie Liu              University of Georgia
    Richard Marsh            California Institute of Technology
    Cory Momany              University of Georgia
    Gary Newton              University of Georgia
    Ward Robinson            Canterbury University, New Zealand
    John Rose                University of Georgia
    Robert Sparks            Bruker Analytical X-ray
    Bi-Cheng Wang            University of Georgia

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                1998 ACA Summer Course Lecture Schedule

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July 5 - DAY 1

Lecture 1: Overview of Using X-rays as an Analytical Tool
Lecture 2: Generation and Characteristics of X-rays
Lecture 3: Preparation of Crystalline Samples

Evening Sessions
E1, E2: Opening Mixer

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July 6 - DAY 2

Lecture 4: Unit Cells, Lattices and Miller Indices
Lecture 5: Symmetry Elements
Lecture 6: Space, Point  and Laue Groups

Evening Sessions
E3: Historical Crystallography
E4: Schattschneider Film on Symmetry

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July 7 - DAY 3

Lecture 7: The Use of International Tables for Crystallography
Lecture 8: X-ray Diffraction and the Reciprocal Lattice
Lecture 9: Symmetry in the Reciprocal Lattice

Evening Sessions
E5, E6: The Basic Mathematics of Crystallography

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July 8 - DAY 4

Lecture 10: Scattering of X-rays by Single Atoms and by Groups of Atoms
Lecture 11: Structure Factors, Fourier Transforms and Electron Density
Lecture 12: Anomalous Scattering

Evening Sessions
E7: Lectures by Representatives of Instrument Manufacturers I
E8: Lectures by Representatives of Instrument Manufacturers II

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July 9 - DAY 5

Lecture 13: Data Collection Instruments
Lecture 14: Data Collection Methods
Lecture 15: Processing of Diffraction Data

Evening Sessions
E9: Advanced Data Collection Methods
E10: Cornell/MacChess Cryocrystallography Film

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July 10 - DAY 6

Lecture 16: Solving the Phase Problem
Lecture 17: Patterson Methods
Lecture 18: Direct Methods I

Evening Sessions
E11: Crystal Twinning
E12: Problem Structures I

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July 11 - DAY 7

Lecture 19: Direct Methods II
Lecture 20: Structure Refinement by Least Squares
Lecture 21: Problem Structures II

Evening Sessions
E13: Advanced Phasing Methods

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July 12 - DAY 8

Lecture 22: Structural Info & Error Analysis
Lecture 23: Structure Report and Publication
Lecture 24: Structural Databases

Evening Sessions
E15, E16: BANQUET

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July 13 - DAY 9

Morning - Student presentations

Afternoon - Macromolecular crystallography sessions begin

Lecture 25: Crystallization of Macromolecules I
Lecture 26: Crystallization of Macromolecules II
Lecture 27: Data Collection Strategies

Evening Sessions
E17: Preliminary Information
E18: Preparation of Heavy Atom Derivatives

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July 14 - DAY 10

Lecture 28: Determination of Heavy Atom Sites
Lecture 29: MIR/SIR
Lecture 30: Anomalous Scattering/ MAD

Evening Sessions
E19: Synchrotron Data Collection
E20: Density Modification

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July 15 - DAY 11

Lecture 31: Molecular Replacement
Lecture 32: Chain Tracing, Mini-maps and Models
Lecture 33: Rigid Body, Constrained/Restrained Least Squares

Evening Sessions
E21: Molecular Averaging
E22: Model Building Programs

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July 16 - DAY 12

Lecture 34: Simulated Annealing
Lecture 35: Stereochemistry and Structural Parameters
Lecture 36: PDB, NDB, NIST, Swiss-Prot, GENBANK and MMCIF

Evening Sessions
E23: Structure Validation Programs
E24: Submitting Data to the Protein Data Bank

--
John P. Rose
Department of Biochemistry & Molecular Biology
University of Georgia, Athens, GA 30602
E-mail rose at BCL4.bmb.uga.edu
http://www.uga.edu/~biocryst







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