Q: structure of protein complex + alanine scan

[Yoram Puius]

Romano Kroemer wrote:
> 
> Hi all,
> 
> can anyone point me to references concerning the following topic:
> 
> Systematic "alanine scanning" studies on protein complexes for which the
>   (wild type)structure is known (by NMR/X-ray).

Try human gelsolin domain 1 in complex with actin.

The structure of the complex was solved by P. J. McLaughlin, preceded
by many mutagenesis papers by Michael Way and colleagues.

Have fun,
	Y

-- 
_______________________________________________________________________
Yoram A. Puius                Albert Einstein College of Medicine
6th year M.D.-Ph.D.           Department of Biochemistry
mailto:puius at aecom.yu.edu     1300 Morris Park Avenue, Bronx, NY  10461
        http://www.geocities.com/Athens/Forum/7504
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    "As a child, I was an imaginary playmate." - Tom Robbins