Q: structure of protein complex + alanine scan

Yoram Puius puius at aecom.yu.edu
Tue Aug 25 22:17:19 EST 1998

Romano Kroemer wrote:
> Hi all,
> can anyone point me to references concerning the following topic:
> Systematic "alanine scanning" studies on protein complexes for which the
>   (wild type)structure is known (by NMR/X-ray).

Try human gelsolin domain 1 in complex with actin.

The structure of the complex was solved by P. J. McLaughlin, preceded
by many mutagenesis papers by Michael Way and colleagues.

Have fun,

Yoram A. Puius                Albert Einstein College of Medicine
6th year M.D.-Ph.D.           Department of Biochemistry
mailto:puius at aecom.yu.edu     1300 Morris Park Avenue, Bronx, NY  10461
    "As a child, I was an imaginary playmate." - Tom Robbins

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