Post-doctoral position at Stockholm University

Marjolein Thunnissen marjo at
Fri Dec 4 11:04:37 EST 1998


There is a post-doctoral position available in the Department of
Biochemistry at Stockholm University to work towards the structure
determination of the membrane protein leukotriene C4 synthase, or
related enzymes such as microsomal glutathione S transferase II
(GST-II). These enzymes are involved in the development of diseases such
as asthma.
For GST-II an over-expression system using a baculovirus insect cell
system is available and large quantities of reasonably pure and
functional protein have been obtained. The goal of the project would be
further purification, crystallisation and subsequent structure
determination of this protein. The project is a collaboration between
the groups of Dr. Marjolein Thunnissen at Stockholm University and Dr.
Jesper Haeggstr=F6m at the Karolinska Institute.

An optimal candidate should have experience in protein purification and
crystallisation. Experience with membrane proteins is a clear advantage.

The position is available immediately. The period is for 1 year with
possibility for extension for another year. The applicant must be a
non-Swedish citizen.

The structural biology group at the Department of Biochemistry of
Stockholm University  is a small unit of crystallographers with a wide
experience in structure determination. The emphasis of the work is on
leukotriene converting enzymes, phosphatases, metalloproteins and
membrane protein crystallography. The group also has broad expertise in
protein expression and purification. The Department of Biochemistry is a
leading institute in research on membrane proteins (e.g. in the groups
of Prof. Bertil Andersson & Prof. Gunnar von Heijne).

Please send curriculum vitae, description of research interests, names
of up to three
referees (or any other inquiries) to:

Dr. Marjolein Thunnissen
Department of Biochemistry
Arrhenius Laboratories A4
S-106 91 Stockholm

Tel: +46 8 162715
Fax: +46 8 153679
e-mail: marjo at

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