PostDoc Protein Chem/Molecular Biol

Mark Knapp knapp14 at
Thu Jul 1 18:59:09 EST 1999

The Macromolecular Crystallography Group at Lawrence Livermore National
Laboratory has an immediate
opening for a Protein Chemist/Molecular Biologist.
Pleas see our website for further details:

]BS 6273 - Postdoctoral Protein Chemist or Molecular Biologist
A postdoctoral position for a Protein Chemist or Molecular Biologist is
available immediately in the
Macromolecular Crystallography group in the Biology and Biotechnology
Research Program on a University of
California Campus-Laboratory-Collaboration (CLC) project on the
structural genomics of Pyrobaculum
Aerophilum (PA).

Nature and Scope of Position:
The individual will work as a member of a research team and be fully
responsible for work on genes from the
extremophile Pyrobaculum Aerophilum as a member of a pilot study on
structural genomics initiated by Prof.
Eisenberg at UCLA. The challenge will be to integrate molecular biology,
biochemistry and crystallography. We
have specific need for cloning, mutagenesis, expression, and
purification skills.  An interest in crystallography is
desirable and some knowledge of crystallography is preferred but not
necessary.  A qualified applicant should
work independently while cloning and over expressing proteins of
interest and should be able to devise
purification protocols.  The current focus of related research efforts
in the macromolecular crystallography group
includes, DNA repair enzymes, bacterial neurotoxins, and lipoproteins.

Essential Duties:
Oversee day-to-day operation of protein expression, purification and
Clone and amplify PA genes of interest from C-DNA libraries
Over express and purify PA proteins
Maintain and expand LLNL PA web pages
Help coworkers and other investigators with expression and purification
Assist in the writing of manuscripts

Help supervise summer students and visiting faculty
Perform routine laboratory safety checks
Manage waste generated in the laboratory

Essential Skills, Knowledge, and Abilities:
Ph.D in the biochemistry, genetics, molecular biology or related fields.

Experience in gene expression and protein purification
Should feel comfortable working with instrumentation and personal
Must be capable of working with minimal supervision and making
independent decisions

Desired Skills, Knowledge, and Abilities:
Previous experience with protein crystallization

TO APPLY, CONTACT: Bernhard Rupp, Biology and Biotechnology Research
Program, L-452, P.O. Box
808, Lawrence Livermore National Laboratory, Livermore, CA 94551,
br at,

Please refer to the posting at our website

Ducks usually lie.
   -- DM Pinkwater
Mark Knapp
Lawrence Livermore National Laboratory
Macromolecular Crystallography Group
Mail Stop L-452    Office: 925-422-5793
7000 East Avenue,  PO Box 808  Fax  :  925-422-2282
Livermore, CA  94550          email:  knapp14 at

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