Polymorphic purity in drugs

Michio Sakabe ms917 at nmt.ne.jp
Sun Feb 20 01:12:45 EST 2000


Dear members,

I am looking for the measures and references to evaluate polymorphs
rate(polymorphic purity) in a drug.

In general, polymorphism is studied by IR,Raman, Thermal analysis, X-ray
diffraction, solid state NMR(ss-NMR) and so on. Especially, for analysis of
each polymorph and amorphous rate in an organic compound(e.g. drug), ss-NMR
or Raman seems to be used. But I'm not clear about ss-NMR and raman, so I
want to know how to measure the polymorph and amorphous rate with ss-NMR or
Raman. Off course, if there are any other methods, I need the information.
Any comments would be appreciated.

Thanks for your help.

Michio
E-mail:  ms917 at nmt.ne.jp






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