ACA Summer Course in Crystallography
John Rose
rose at bcl4.bmb.uga.edu
Sat May 20 15:16:09 EST 2000
**** Scholarships are still Available ****
American Crystallographic Association
Summer Course in Crystallography
July 07 to July 19 2000
Georgia Center for Continuing Education
University of Georgia
Athens, GA
The ninth annual ACA Summer Course in Crystallography will be a 12 day
course
held from July 7 to July 19, 2000 at the University of Georgia, Athens
GA.
New this year, the first seven days of the course will be devoted to
basic
crystallography of small molecules and will include lectures on the
mathematics and physics behind structural analysis, the methods of
structure
solution, the refinement of atomic parameters and the presentation and
analysis of the results of a structure determination. The laboratory
associated with this part of the course will teach the students to
select and
mount small molecule crystals, determine their unit cell dimensions and
collect data on modern equipment. They will learn to use modern
crystallographic software packages to determine space groups as well as
solve
and refine structures. Finally, they will present a brief report on
their
results.
The final five days of the course will be devoted to macromolecular
crystallography and include lectures on crystallization, data collection
and
processing, determination of heavy atom sites, structure solution by
MIR,
SIR, MAD, SAS and molecular replacement techniques, chain tracing, model
building and refinement methods.
The laboratory associated with this part of the course will include
workshops
on (1) the crystallization of proteins (light scattering, crystal
screens,
robotics), (2) crystal mounting and data collection, (3) SHAKE-N-BAKE
and
(4) methods for phase calculation using SAS data.
The University of Georgia (UGA) has instruments from all four major
vendors:
Bruker (Smart 1000 and 6000 CCD detectors), MarResearch (30 cm image
plate),
Nonius (Kappa CCD) and Rigaku (R-Axis IV). Students will have access to
the
latest versions of DENZO-SMN/maXus (Nonius), SMART/SAINT/SHELXTL
(Bruker) and
CRYSTALCLEAR/TEXSAN (Rigaku) as well as HKL, D*TREK, ISIR/ISAS, PHASES,
SHAKE-N-BAKE, SOLVE, O, X-PLOR and CNS.
A tentative list of lecturers includes:
Charles Campana, Bruker Analytical X-ray
Chung-Jung Chen, University of Georgia
Wally Cordes, University of Arkansas
Thomas Concolino, Molecular Structure Corporation
Bryan Craven, Indiana University, Pennsylvania
Steve Geib, University of Pittsburgh
Dan Frankel, Nonius
Steven Foundling, Bruker Analytical X-ray
Herbert Hauptman, Hauptman-Woodward Medical Research Institute
Andrzej Joachimiak, Structural Biology Center Argonne National
Laboratory
Doowon Lee, Georgia State University
Zhi-Jie Liu, University of Georgia
Richard Marsh, California Institute of Technology
Cory Momany, University of Georgia
Gary Newton, University of Georgia
Ward Robinson, Canterbury University, New Zealand
John Rose, University of Georgia
Bram Schierbeek, Nonius
Robert Sparks, Bruker Analytical X-ray
Robert Sweet, Brookhaven National Laboratory
Kris Tesh, Molecular Structure Corporation
Bi-Cheng Wang, University of Georgia
Charles Weeks, Hauptman-Woodward Medical Research Institute
Others to be arranged, please check the Summer Course web page
In addition, experienced laboratory instructors will be available for
each of
the laboratory sessions.
The text chosen for the summer school is "Crystal Structure Analysis" by
Glusker and Trueblood. A complete set of lecture notes will be provided
to
each student.
Tuition for the course will be $750. Admission will be limited to
approximately 45-50 students. A number of full and partial tuition
scholarships will be provided on a competitive basis. The criteria for
these
awards are (1) expected benefits from the course, (2) qualification (3)
motivation and (4) need.
Accommodations have been reserved at UGA from the evening of July 6; the
rate for these air-conditioned rooms will be $28 per day single, or $20
per
day double occupancy. Student housing is only a short walk from where
the
lectures will be given and from the laboratories with the X-ray
equipment
that will be used. There are several local hotels within walking
distance
to both the lecture hall and X-ray diffraction facilities.
For more information and registration materials please see:
BCL5.bmb.uga.edu/aca2k.html or www.uga.edu/~biocryst
or contact:
Dr. Gary Newton
Department of Biochemistry and Molecular Biology
University of Georgia
Athens, GA 30602
Telephone: (706) 542-3272
FAX : (706) 542-3077
E-mail : newton at chem.uga.edu
******> APPLICATION FORMS MUST BE RETURNED TO DR. NEWTON BY JUNE 15,
2000 <******
---------------------------- Course Outline ----------------------------
2000 ACA Summer Course Outline and Schedule
Day 0 Thursday, July 6 Lobby Georgia Center
Afternoon
2:00 - 10:00 Arrival and Registration
------------------------------------------------------------------------
DAY 1 Friday, July 7 Room R Georgia Center
Morning
8:15 - 8:30 Welcome to Athens and Opening Remarks
8:30 - 9:30 Generation and Characteristics of X-rays
9:30 - 9:40 Break
9:40 - 10:40 Preparation of Crystalline Samples
10:40 - 11:00 Break
11:00 - 12:00 Unit Cells, Lattices and Miller Indices
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 5:00 Laboratory Sessions (locations to be announced)
Evening
6:00 - 9:00 Commons Room Life Sciences Building
Opening Mixer (food and drink provided)
------------------------------------------------------------------------
DAY 2 Saturday, July 8 Room R Georgia Center
Morning
8:30 - 9:30 Symmetry Elements
9:30 - 9:40 Break
9:40 - 10:40 Space, Point and Laue Groups
10:40 - 11:00 Break
11:00 - 12:00 Use of International Tables for Crystallography
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 5:00 Laboratory Sessions
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Historical Crystallography
Symmetry
------------------------------------------------------------------------
DAY 3 Sunday, July 9 Room R Georgia Center
Morning
8:30 - 9:30 X-ray Diffraction and the Reciprocal Lattice
9:30 - 9:40 Break
9:40 - 10:40 Symmetry in the Reciprocal Lattice
10:40 - 11:00 Break
11:00 - 12:00 Scattering by Single Atoms and Groups of Atoms
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 5:00 Laboratory Sessions
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Basic Mathematics of Crystallography
------------------------------------------------------------------------
DAY 4 Monday, July 10 Room R Georgia Center
Morning
8:30 - 9:30 Structure Factors, Fourier Transforms, Electron Density
9:30 - 9:40 Break
9:40 - 10:40 Anomalous Scattering
10:40 - 11:00 Break
11:00 - 12:00 Solving the Phase Problem
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 5:00 Laboratory Sessions
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Talks by Representatives of Instrument Manufacturers
Bruker
MarResearch
Nonius
Rigaku (MSC)
------------------------------------------------------------------------
DAY 5 Tuesday, July 11 Room R Georgia Center
Morning
8:30 - 9:30 Patterson Methods
9:30 - 9:40 Break
9:40 - 10:40 Data Collection Methods
10:40 - 11:00 Break
11:00 - 12:00 Processing of Diffraction Data
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 5:00 Laboratory Sessions
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Data Collection Instruments
------------------------------------------------------------------------
DAY 6 Wednesday, July 12 Room R Georgia Center
Morning
8:30 - 9:30 Direct Methods
9:30 - 9:40 Break
9:40 - 10:40 Advanced Phasing Methods
10:40 - 11:00 Break
11:00 - 12:00 Structure Refinement by Least Squares
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 5:00 Laboratory Sessions
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Problem Structures
Crystal Twinning
------------------------------------------------------------------------
DAY 7 Thursday, July 13 Room R Georgia Center
Morning
8:30 - 9:30 Structural Info & Error Analysis
9:30 - 9:40 Break
9:40 - 10:40 Structure Report and Publication
10:40 - 11:00 Break
11:00 - 12:00 Structural Databases
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 5:00 Room R Georgia Center
STUDENT PRESENTATIONS
Evening
7:00 - 9:00 Georgia Center Banquet Area
BANQUET
------------------------------------------------------------------------
FRIDAY, JULY 14 - REST DAY
------------------------------------------------------------------------
DAY 8 Saturday, July 15 Room R Georgia Center
MACROMOLECULAR SESSIONS BEGIN
Morning
8:30 - 9:30 Crystallization of Macromolecules
9:30 - 9:40 Break
9:40 - 10:40 Data Collection Strategies, Preliminary Information
10:40 - 11:00 Break
11:00 - 12:00 Using Shake-N-Bake
12:00 - 1:30 LUNCH (on your own)
Afternoon - Mini-Workshops (locations to be announced)
1:30 - 5:00 Group A Shake-N-Bake Workshop
1:30 - 5:00 Group B Protein Data Collection Workshop
1:30 - 5:00 Group C Crystallization Workshop
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Cryocrystallography
------------------------------------------------------------------------
DAY 9 Sunday, July 16 Room R Georgia Center
Morning
8:30 - 9:30 Overview of MIR/SIR/MAD/SAD
9:30 - 9:40 Break
9:40 - 10:40 Heavy Atom Derivatives
10:40 - 11:00 Break
11:00 - 12:00 Determination of Heavy Atom Positions
12:00 - 1:30 LUNCH (on your own)
Afternoon - Mini-Workshops
1:30 - 5:00 Group B Shake-N-Bake Workshop
1:30 - 5:00 Group C Protein Data Collection Workshop
1:30 - 5:00 Group A Crystallization Workshop
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Synchrotron Data Collection at SBC
------------------------------------------------------------------------
DAY 10 Monday, July 17 Room R Georgia Center
Morning
8:30 - 9:30 MAD Theory
9:30 - 9:40 Break
9:40 - 10:40 SAS Theory
10:40 - 11:00 Break
11:00 - 12:00 The ISAS Procedure
12:00 - 1:30 LUNCH (on your own)
Afternoon - Mini-Workshops
1:30 - 5:00 Group C Shake-N-Bake Workshop
1:30 - 5:00 Group A Protein Data Collection Workshop
1:30 - 5:00 Group B Crystallization Workshop
5:00 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Room R Georgia Center
Synchrotron Data Collection at NSLS
------------------------------------------------------------------------
DAY 11 Tuesday, July 18 Room R Georgia Center
Morning
8:30 - 9:30 Molecular Replacement
9:30 - 9:40 Break
9:40 - 10:40 Model Building
10:40 - 11:00 Break
11:00 - 12:00 Stereochemistry and Structural Parameters
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 3:30 Group A ISAS Workshop
3:40 - 5:40 Group B ISAS Workshop
5:40 - 7:00 DINNER (on your own)
Evening
7:00 - 9:00 Data Collection via the WWW at NSLS
------------------------------------------------------------------------
DAY 12 Wednesday, July 19 Room R Georgia Center
Morning
8:30 - 9:30 Refinement and Simulated Annealing
9:30 - 9:40 Break
9:40 - 10:40 Structure Validation
10:40 - 11:00 Break
11:00 - 12:00 Data Bases and the WWW
12:00 - 1:30 LUNCH (on your own)
Afternoon
1:30 - 3:30 Group C ISAS Workshop
3:40 - 5:00 ISAS Workshop (continued for all interested parties)
5:00 COURSE ENDS
5:30 - 7:00 Commons Room Life Sciences Building
PIZZA PARTY
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