aminoacid sequence of subunit alpha of neuronal nAch receptors

rcamsonn at hgmp.mrc.ac.uk rcamsonn at hgmp.mrc.ac.uk
Thu Sep 28 10:55:18 EST 2000


The alpha subunit of nAchR is known to have 2 binding sites. One is dedicated 
to its activation/inactivation by both agonist and antagonist (competitive
antagonist) and another for its regulation owing to the specific binding 
of its non competitive antagonist represented by a chemical molecule called 
Mecamylamine.
I'd like to know the precise aminoacid sequences to which both competetive and
non competitive antgonists bind, if any.
Thank very much for your next help.
Dr Rudolphe Camsonne
Molecular Pharmacology, CHU of Caen 14033 France


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