Position available - Wim Hol (2)

Heidi Singer hragland at u.washington.edu
Tue Jul 10 19:08:24 EST 2001


POSITION OPEN: POSTDOCTORAL FELLOW - Crystallography of Cholera Toxin
Secretion

JOB DESCRIPTION: Applications are invited for a postdoctoral position in
Wim Hol's group on a project aiming at understanding the secretion of
cholera toxin and its close relative heat-labile enterotoxin at the
structural level. These toxins are responsible for a large number of
victims among young children in developing countries as well as in
natural disaster areas.
     In Vibrio cholerae these intriguing heterohexameric AB5 toxins
interact with a fascinating set of so-called “Eps proteins” which
translocates them across the outer membrane. The goal of the project is
to unravel the interactions of the toxin with the proteins responsible
for toxin secretion. Most remarkably, the toxin remains folded during
the translocation process. Collaborations are in place regarding the Eps
proteins. Excellent expression systems for the toxins are available
already.
     Experience with molecular biology and protein crystallographic
methods is essential, and familiarity with membrane proteins would be
very welcome.

INSTITUTION:   Department of Biochemistry & Howard Hughes Medical
Institute
                           Biomolecular Structure Center
                           School of Medicine
                           University of Washington
                           Box 357742
                           Seattle, WA, 98195  USA


SCIENTIFIC ENVIRONMENT: The research will take place within the
framework of the Biomolecular Structure Center of the University of
Washington. The Center brings together several groups involved in
Structural, Chemical and Computational Biology and is well equipped with
area detectors, calorimeters, fluorimeters, chromatography systems and
state of the art instruments for protein expression, purification and
crystallization. The School of Medicine of the University of Washington
provides an exceptionally rich scientific environment. In addition,
close interactions exist with the Department of Chemistry in relation to
several structure-guided drug design projects.

WHAT TO DO: Please send a full CV, list of publications, a brief
description of research interests and experience, plus a list of three
references by mail or email to Wim Hol.

PHONE:  206-685-7044
FAX:  206-685-7002
EMAIL:  hol at gouda.bmsc.washington.edu
WEBSITE:  http://www.bmsc.washington.edu/WimHol








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