Position available - Wim Hol (3)

Heidi Singer hragland at u.washington.edu
Tue Jul 10 19:09:29 EST 2001


POSITION OPEN:  POSTDOCTORAL FELLOW - Crystallography of Tropical
Proteins

JOB DESCRIPTION:  Applications are invited for a postdoctoral position
in Wim Hol's group on a project aimed at solving structures of key
proteins from important pathogenic protozoa responsible for several of
the most rampant diseases worldwide, including malaria, sleeping
sickness, Chagas' disease, and the several forms of leishmaniases. The
goal is to arrive at selective inhibitors of proteins involved in (i)
the biogenesis of unique organelles such as glycosomes; (ii) protein
farnelysation; (iii) cholesterol synthesis, and of other crucial
processes in these pathogens.
In several cases superb inhibitors are already available and a structure
of the protein-inhibitor complex would be of tremendous help in
advancing the design of better compounds. An international
multi-disciplinary network of collaborations is in place for computer
modeling, chemical synthesis and testing of compounds in vitro and in
vivo.
Experience with protein crystallographic methods is required. Knowledge
of molecular modeling techniques would be helpful. Enthusiasm for
tackling one or more membrane proteins, along with some water soluble
proteins, would be very welcome.

INSTITUTION:   Department of Biochemistry & Howard Hughes Medical
Institute
                           Biomolecular Structure Center
                           School of Medicine
                           Box 357742
                           University of Washington
                           Seattle, WA, 98195  USA

SCIENTIFIC ENVIRONMENT: The research will take place within the
framework of the Biomolecular Structure Center of the University of
Washington. The Center brings together several groups involved in
Structural, Chemical and Computational Biology and is well equipped with
area detectors, calorimeters, fluorimeters, chromatography systems and
state of the art instruments for protein expression, purification and
crystallization. The School of Medicine of the University of Washington
provides an exceptionally rich scientific environment. In addition,
close interactions exist with the Department of Chemistry in relation to
several structure-guided drug design projects.

WHAT TO DO: Please send a full CV, list of publications, a brief
description of research interests and experience, plus a list of three
references by mail or email to Wim Hol.

PHONE:  206-685-7044
FAX:  206-685-7002
EMAIL:  hol at gouda.bmsc.washington.edu
WEBSITE:  http://www.bmsc.washington.edu/WimHol







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