Position available - Wim Hol (5)

Heidi Singer hragland at u.washington.edu
Tue Jul 10 19:11:42 EST 2001

POSITION OPEN:  RESEARCH SCIENTIST - Protein cloning, expression and
purification of cholera toxin and partner proteins.

JOB DESCRIPTION:  Applications are invited for a Research Scientist
position in Wim Hol's group on a project aiming at solving protein
structures of  cholera toxin and it close relative heat-labile
enterotoxin. These heterohexameric AB5 proteins interact during there
fascinating life cycle with numerous proteins in the periplasm of Vibrio
cholerae, with ganglioside receptors on the human target epithelial
cells, and with several proteins inside these cells. Goals of the
project are to understand the interactions of the toxins with the
proteins and receptors they are encountering as well as to design
inhibitors for these recognition processes.
 Excellent expression systems of the toxins are already available. A
network of collaborating groups is in place to study the functional
aspects of toxins action as well as to design and synthesize novel
inhibitors of the various intermolecular interactions these
sophisticated toxins engage in.

JOB REQUIREMENTS:  A Ph.D. or B.Sc. in Biochemistry or Molecular
Biology, with experience in cloning, expression and purification of
proteins.  Experience with membrane proteins would be welcome.

INSTITUTION:   Department of Biochemistry & Howard Hughes Medical
                           Biomolecular Structure Center
                           School of Medicine
                           Box 357742
                           University of Washington
                           Seattle, WA, 98195  USA

SCIENTIFIC ENVIRONMENT: The research will take place within the
framework of the Biomolecular Structure Center of the University of
Washington. The Center brings together several groups involved in
Structural, Chemical and Computational Biology and is well equipped with
area detectors, calorimeters, fluorimeters, chromatography systems and
state of the art instruments for protein expression, purification and
crystallization. The School of Medicine of the University of Washington
provides an exceptionally rich scientific environment. In addition,
close interactions exist with the Department of Chemistry in relation to
several structure-guided drug design projects.

WHAT TO DO: Please send a full CV, list of publications, a brief
description of research interests and experience, plus a list of three
references by mail or email to Wim Hol.

PHONE:  206-685-7044
FAX:  206-685-7002
EMAIL:  hol at gouda.bmsc.washington.edu
WEBSITE:  http://www.bmsc.washington.edu/WimHol

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