[Protein-crystallography] Lipase substrate analogue

Clement Angkawidjaja clement at bio.mls.eng.osaka-u.ac.jp
Fri Sep 8 00:15:11 EST 2006


Hi, I am working on a project for the crystallization of a bacterial lipase. 
I got some good crystals on the native enzyme, and I also want to 
crystallize the enzyme in complex with a substrate analogue (inhibitor). I 
used the commercially-available paraoxon (also called E600), but no 
inhibition occured. Does anyone know any company that sells lipase substrate 
analogue such as fatty-acid conjugated phophonates? Any suggestion will be 
highly appreciated. Thank you.

Clement Angkawidjaja
Osaka University, Japan 



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