[Protein-crystallography] Quips about greasy pockets

Gerard DVD Kleywegt via xtal-log%40net.bio.net (by gerard from xray.bmc.uu.se)
Wed Sep 14 10:58:04 EST 2011


Hi all,

As you may recall, the Protein Data Bank in Europe (PDBe; pdbe.org) regularly 
produces Quips, short stories about QUite Interesting Pdb Structures 
(pdbe.org/quips). Quips address biologically interesting aspects of one or more 
PDB entries, coupled with interactive graphics views and often a mini-tutorial 
or suggestions for further exploration using PDBe services and resources.

Today another Quips episode was released. It is about autotaxins, 
physiologically important proteins that are pursued as anti-cancer drug 
targets. This Quips was developed together with scientists from the Netherlands 
Cancer Institute (Tassos Perrakis and Wouter Moolenaar) to accompany their 
review paper in Nature Reviews Molecular Cell Biology on autotaxin structure 
and function that was also published today.

- For the Quips story ("Autotaxins: inhibiting a greasy pocket"), go to: 
http://pdbe.org/quips?story=Autotaxin

- For the review paper ("Insights into autotaxin: how to produce and present a 
lipid mediator"), go to: 
http://www.nature.com/nrm/journal/vaop/ncurrent/full/nrm3188.html

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If you have an interesting structure whose story you would like to tell (with 
our help) in the form of a Quips episode, please contact us at pdbe from ebi.ac.uk

--Gerard

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Gerard J. Kleywegt, PDBe, EMBL-EBI, Hinxton, UK
gerard from ebi.ac.uk ..................... pdbe.org
Secretary: Pauline Haslam  pdbe_admin from ebi.ac.uk



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