Postdoctoral Research Associate =96 Macromolecular Crystal Preparation for =
NSLS-II
2-year Term Position
BNL Overview:
Brookhaven National Laboratory is a nonprofit research and development inst=
itution whose purpose is to advance ideas and knowledge through a multidisc=
iplinary program of basic and applied research.
Project Overview:
A postdoctoral position is available to develop new crystal-preparation tec=
hnologies to advance the use of serial macromolecular crystallography (MX) =
at NSLS-II. This new synchrotron will soon begin operation at Brookhaven Na=
tional Laboratory. The individual will develop technologies for crystalliza=
tion, drug discovery, and crystal handling to make serial crystallography p=
ossible, using various technologies, including acoustic droplet ejection (A=
DE).
The project will provide the capability for experimenters to employ nanolit=
er quantities of material to produce specimens for diffraction studies with=
a large number of discrete experiments in a small area. This will exploit =
the micro-beam capabilities of NSLS-II MX beamlines; both room temperature =
and cryogenic serial crystallography strategies will be explored. High-thro=
ughput screening will be used for different types of structural biology pro=
jects (crystallization conditions, fragment binding, etc). The individual w=
ill work closely with a broad technology-development team. Our team members=
have different areas of expertise, from 3D labware design to research on m=
edically relevant expressed proteins. No experience with ADE is necessary.
Essential Duties and Responsibilities:
The successful candidate will assist in the development and implementation =
of procedures and computer algorithms that leverage the Echo 550 instrument=
for macromolecular crystallography applications for serial crystallography=
applications in the few-nanoliter regime. The candidate will also develop =
novel technologies as well as improve existing technologies, and will have =
opportunities to participate in other related projects in a large and diver=
se group.
Required Knowledge, Skills and Abilities:
* Ph.D. in an appropriate chemistry, biology, or physics discipline; st=
ructural biology, crystallography, or a related field will have preference
* Demonstrated experience (preferably including publications) in innova=
tive experimentation and/or methods development with crystallography or dru=
g discovery
* Experience with conventional crystallization, and familiarity with mi=
cro crystallization and handling of micro crystals will be valuable
* Experience in computer programming
* The candidate must have a demonstrated ability to work with a team.
Other Information:
BNL policy states that Research Associate appointments may be made to those=
who have received their doctoral degrees within the past five years.
Please apply to Job # 137 on our jobs website:
http://www.bnl.gov/HR/careers/
At Brookhaven National Laboratory we believe that a comprehensive employee =
benefits program is an important and meaningful part of the compensation em=
ployees receive. Our benefits program includes but is not limited to:
* Medical Plans
* Vacation
* Holidays
* Dental Plans
* Life Insurance
* 401(k) Plan
* On-site Child Development Center, Swimming Pool, Weight room Tennis C=
ourts, and many other employee perks and benefits.
