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<HTML> <TT>*** Second and Final Announcement ***</TT><TT></TT> <TT>Molecular Simulations announces a major International Symposium, "New</TT> <TT>Approaches in Pharmaceutical Development".  This event will be held on</TT> <TT>February 19th and 20th, 1998, in San Diego, California.</TT><TT></TT> <TT>As shown below in the Symposium program, the main topics will be new</TT> <TT>computational and experimental techniques relevant to the crystallization</TT> <TT>and formulation of organic compounds.  The event will be of interest to</TT> <TT>anyone involved in pharmaceutical development, as well as researchers and</TT> <TT>managers in industries such as agrochemicals, pigments, explosives, and</TT> <TT>other fine chemicals.</TT><TT></TT> <TT>This Symposium will be held immediately after the first worldwide meeting</TT> <TT>of MSI’s Pharmaceutical Development Consortium.  The Consortium brings</TT> <TT>together commercial research organizations, MSI’s expert staff, and a panel</TT> <TT>of academic advisors to drive a research program focused on developing</TT> <TT>simulation methods to address problems in pharmaceutical development and</TT> <TT>formulation.</TT><TT></TT> <TT>Registration for the Symposium is free of charge and includes lunches,</TT> <TT>reception, and the Symposium dinner.  The venue will be the Princess Resort</TT> <TT>Island in Mission Bay, San Diego, which combines an idyllic setting with</TT> <TT>state-of-the-art facilities and services.</TT><TT></TT> <TT>Attendees are cordially invited to present their work at the poster</TT> <TT>session.  If you are interested in attending, please contact Deborah Kelso</TT> <TT>at MSI’s headquarters in San Diego (fax +1 (619) 458-0136, or e-mail</TT> <TT>dak@msi.com).  Further details will be posted at MSI’s web site,</TT> <TT><A HREF="http://www.msi.com/info/consortia/pdc/Symposium.html">http://www.msi.com/info/consortia/pdc/Symposium.html</A>.</TT><TT></TT> <TT>NEW APPROACHES IN PHARMACEUTICAL DEVELOPMENT</TT><TT></TT> <TT>Thursday 19 February 1998</TT> <TT>9:00   Opening</TT> <TT>9:15   Dr. Stephen Byrn, Purdue University, USA</TT> <TT>        "Solid State Chemistry - Regulations and Reactions"</TT> <TT>10:30  Coffee Break</TT> <TT>11:00  Dr. William David and Dr. Kenneth Shankland,</TT> <TT>       Rutherford Appleton Laboratory, UK</TT> <TT>        "Crystal Structure Determination from Powder Diffraction</TT> <TT>         Data"</TT> <TT>12:15  Lunch</TT> <TT>13:45  Dr. Gautam Desiraju, Hyderabad University, India</TT> <TT>        "Relevance of Crystal Engineering and Molecular Modeling</TT> <TT>         in Pharmaceutical Industry"</TT> <TT>15:00  Tea Break</TT> <TT>15:30  Dr. Heinrich Karfunkel, Tübingen University, Germany</TT> <TT>        "Polymorph Prediction and Beyond"</TT> <TT>16:45  Poster Session and Reception</TT> <TT>19:30  Symposium Dinner</TT><TT></TT> <TT>Friday 20 February 1998</TT> <TT>9:00   Dr. Peter York, Bradford University, UK</TT> <TT>        "Modeling of Particle Surfaces - Applications in Drug</TT> <TT>         Delivery Design"</TT> <TT>10:15  Coffee Break</TT> <TT>10:30  Dr. Kenneth Morris, Purdue University, USA</TT> <TT>        "Identifying Morphology Based Flow Differences Using</TT> <TT>         Cerius2, X-ray Diffraction and Microscopy"</TT> <TT>11:45  Lunch</TT> <TT>13:15  Dr. Piet Bennema, Nijmegen Univ., the Netherlands</TT> <TT>        "Advanced Morphology Analysis Tools - The Importance of</TT> <TT>         Connected Nets"</TT> <TT>14:30  Tea Break</TT> <TT>14:45  Dr. Allan Myerson, Brooklyn Polytechnic, USA</TT> <TT>        "Thermodynamic and Spectroscopic Studies of</TT> <TT>         Supersaturated Solutions"</TT> <TT>16:00  Break</TT> <TT>16:15  Round Table Discussion</TT> <TT>17:30  Close</TT><TT></TT> <TT>*** End of announcement ***</TT><TT></TT> <TT> --------------------------------------------------------</TT> <TT> Mark C. Wahle, Ph.D.        |  Phone: (314) 849-5852</TT> <TT> Applications Scientist      |  Fax:   (314) 849-5863</TT> <TT> Molecular Simulations Inc.  |  Email: wahle@msi.com</TT> <TT> 9641 Chancelorsville Drive  |  Web:   <A HREF="http://www.msi.com">http://www.msi.com</A></TT> <TT> St. Louis, MO  63126        |</TT> <TT> --------------------------------------------------------</TT></HTML>

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