"Poison Complex"?

A.CARMEN mg at ewald.mbi.ucla.edu
Wed Dec 21 21:54:53 EST 1994


I'm having a mind-boggling genetic problem:  my favorate gene (MFG1)
deletion is not lethal and not synthetic lethal with a non-null mutation
of another gene (MFG2) in haploid cells, but deletion of one copy of MFG1
in a dipoid is synthetically lethal with that particular mutation in
MFG2.  Does anybody know of such or similar genetic interactions?  One
case comes to my mind is that the mutant MFG2 protein may form a "poison
complex" with MFG1.  Any suggestions?



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