Summary: multicopy suppression by CEN plasmid

David Stillman stillman at bioscience.utah.edu
Thu Feb 24 17:06:16 EST 1994


I posted the following question on the net: 
Are there other cases of multicopy suppression from a CEN plasmid?  
I received a number of replies. Here is a summary.

Examples of multicopy suppression in a CEN plasmid. 

SSD1/SRK1 on a CEN plasmid suppresses slk1 
Costigan, Gehrung, and Snyder, 1992
Mol. Cell. Biol. 12, p1162-1178

REG1 on a CEN plasmid suppresses gal82 and gal83
Erickson and Johnston, 1993
Genetics 135, 655-664

Ef-1alpha on a CEN plasmid suppresses asu9 
Song et al., 1989
Mol. Cell. Biol. 9, 4571-4575

RPO26 on a CEN plasmid suppresses rpo21-4 
Archambault, Schapperrt and Friesen, 1990
Mol. Cell. Biol. 10, 6123-6131 

SEC5 on a CEN plasmid suppresses sec15-1
Salminen and Novick, 1987
Cell 49, 527-538

TEF3 on a CEN plasmid suppresses drs2 
Ripmaster, Vaughn, and Woolford, 1993
Mol. Cell. Biol. 13, 7901-7912

MKK4 on a CEN plasmid suppresses stt4/pkc1 
Yoshida et al. (1994) MGG in press; see also Yoshida et al. (1994) JBC
269:1166

CYR1 on a CEN plasmid suppresses ras2 
Mitsuzawa, Uno, Oshima, and Ishikawa, 1989
Genetics 123, 739-748

Other examples of suppression by a gene on a CEN plasmid (no references,
except for sec5, above)
SAR1 suppresses sec12 and sec16
SEC4 suppresses sec1, sec2, sec5, sec8, sec10, sec15, and sec19

Thanks to all who responded.

David Stillman
stillman at bioscience.utah.edu



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