Half-life of Proteins
Robin L. Wright
wrightr at ZOOLOGY.WASHINGTON.EDU
Thu May 5 19:52:12 EST 1994
Randy Hampton and Jasper Rine have an interesting paper in Journal of
Cell Biology that demonstrates regulated degradation of an ER
membrane protein, HMG-CoA redcutase. What is especially interesting
is that there are two isozymes, and each has a different pattern of
half-life control. One is very stable (no turnover for at least 4
hours), and the other has a half-life of about 1 hour.
For those who study protein turnover in general: is it more common
for a yeast protein to be short-lived or to be stable?
If you have measured the half-life of your favorite protein, I would
appreciate hearing from you. I would be happy to compile the data
and post on the net.
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