stop-supression

Preston Garrison garrisonp at THORIN.UTHSCSA.EDU
Mon Oct 31 13:08:46 EST 1994


Hans Klump wrote:
>Hi buddies!
>Is it possible or better: likely that a yeast strain can translate 
>through two different following stopcodons (UGA,UAA) at the end of a 
>gene, say by having a certain amount of supressor tRNAs in the 
>tRNA-pool or something like that?
>Thanks in advance,
>Hannes.
> 
>
There are yeast mutations called omnipotent suppressors, which are defined 
as suppressors that can supress than one type of mutation. The most 
commonly isolated are sup35 and sup45 (which have gone by a number of 
names). There are others, including SUP44 and SUP46, which are ribosomal 
proteins. For a review, see the section on omnipotent suppression in the 
chapter by Hinnebusch and Liebman in Mol and Cellular Biol of the Yeast 
Saccharomyces, Cold Spring Harbor Lab Press , 1991. Also, PNAS 90: 9538 
1993.

Hope this helps,


Preston Garrison                 garrisonp at uthscsa.edu
Biochem. Dept.                   voice: 210-567-3702
Univ Texas Health Sci Ctr        fax:   210-567-6595
San Antonio, Tx 78284-7760
USA



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