Job

Bertrand Seraphin Bertrand.Seraphin at EMBL-Heidelberg.DE
Tue Apr 18 09:55:41 EST 1995


Funded research post-doctoral position available immediately=20
in the laboratory of B. Seraphin in the Gene Expression=20
Programme at EMBL Heidelberg, Germany to study RNA splicing=20
and processing in yeast as well as small nuclear=20
RiboNucleoProtein (snRNP) synthesis in yeast and mammalian=20
systems. Studies are focused on (but not limited to):
a) splice site selection and splicing catalysis;
b) intron recognition by the splicing machinery;
c) protein-RNA interactions and spliceosomal snRNP assembly,=20
particularly function of the Sm proteins;
d) structure-function of the RNase P and MRP=20
RiboNucleoProteins.

Recent publications include:
Seraphin, B. and S. Kandels-Lewis, 3=AB splice site=20
recognition in S. cerevisiae does not require base pairing=20
with U1 snRNA (1993). Cell, 73, 803-812;   Kandels-Lewis, S.=20
and B. Seraphin (1993), Role of U6 snRNA in 5' splice site=20
selection. Science, 262, 2035-2039;   Lygerou, Z., et al.=20
(1994), The POP1 gene encodes a protein component common to=20
the RNase MRP and RNase P ribonucleoproteins. Genes & Dev.,=20
8, 1423-1433;   Seraphin, B (1995). Sm and Sm-like proteins=20
belong to a large family: identification of proteins of the=20
U6 as well as the U1, U2, U4 and U5 snRNPs. EMBO J. in=20
press.

Additional projects in the eight other labs of the Gene=20
Expression Programme are targeted to the analysis of RNA=20
processing, transport and translation as well as=20
transcription. EMBL provides an exceptional scientific=20
environment with excellent facilities.

This position is funded for 12 month with possibilities of=20
extension. Interested candidates with general background in=20
molecular biology should send a C.V. to B. Seraphin by E-
mail (Seraphin at EMBL-Heidelberg.DE) or by mail to B.=20
Seraphin, EMBL, Meyerhofstrasse1, D-69117 Heidelberg,=20
Germany.




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