I have a Yeast question that I hope someone in the group can answer. In
bacteria the conversion of chorismate to para-hydroxybenzoate (PHB) is the
first step in ubiquinone biosynthesis. The reaction is carried out by the
enzyme chorismate pyruvate lyase (CPL) encoded by the ubiC gene. In a search
of the literature I have not been able to find any references to a CPL activity
in Yeast. Is it known that chorismate is converted directly to PHB in Yeast as
part of ubiquinone synthesis, or is the PHB derived from a different pathway?
If it is a direct conversion it would seem that petite mutants blocked
at this step would have been isolated and described in the literature. Have I
missed something or is there a gap in the information on this pathway?