Montreal, CANADA POST-DOC: Yeast Zinc Finger Protein Target genes!!!
francis at borduas.nlm.nih.gov
Mon Apr 29 07:20:31 EST 1996
[ Article crossposted from bionet.jobs.offered ]
[ Author was Graham Dellaire (dellaire at odyssee.net) ]
[ Posted on 23 Apr 1996 09:44:33 -0700 ]
Target genes of the family of yeast zinc cluster transcriptional
Position: Postdoc (salary support available)
Requirements: Ph.D. and experience with techniques in molecular biology
Description of the project: Among the organisms that are used as models
for genomic projects, baker's yeast (Saccharomyces cerevisiae) will be,
in few months, the first one with the complete DNA sequence of all its
chromosomes determined. Given that yeast has a small genome size (13.5
millions base pairs), its ease of manipulation in the laboratory, and
that many processes are highly conserved from yeast to human, it
constitutes a powerful model.
As a result, many studies are aimed at identifying the role of the
various open reading frames, (segments of DNA that encode proteins),
many of which were revealed by the yeast sequencing project. However,
less attention has been paid to the analysis of promoters that are short
DNA segments that control the expression of genes. These sequences can
be easily located in yeast. The aim of this project is to identify
putative target sites of a family DNA binding proteins by searching a
database with sequences that are recognized by members of this family.
Predictions made from the search will then be verified experimentally.
These studies should allow the identification of various gene networks.
In addition, the information obtained should be useful in designing
strategies to analyze gene networks in more complex organisms.
Bernard Turcotte, Assistant Professor, Dept. of Medicine, McGill
Lab. Molecular Endocrinology,Room H7.82
Royal Victoria Hospital
687 Pine Ave. West
Montreal H3A 1A1
Tel. 514-842-1231 Ext. 5046
| B.F. Francis Ouellette
| francis at ncbi.nlm.nih.gov
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