problem in 2-hybrid screen?
tchang at magnus.acs.ohio-state.edu
Thu Jan 11 09:49:01 EST 1996
A colleague of mine was told by others that a highly basic protein
used as a bait in the 2-hybrid screen will unavoidably yield numerous unwanted
false positives, as it presumably will interact, nonspecifically, with many
acidic proteins. I wonder whether anyone know of this type of rumor (or truth)
? Thanks in advance for input in this matter.
Department of Molecular Genetics
The Ohio State University
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