muT homolog

Preston Garrison garrisonp at uthscsa.edu
Tue Apr 8 17:36:11 EST 1997


>I then did a blastp with with the E. coli mutT AA sequence against the
>complete yeast genome AA sequences, a 'blastable' database we maintain
>and update at NCBI, on our blast server: 
>
>http://www.ncbi.nlm.nih.gov/BLAST/
>
>and didn't pick up too much. The alignment of the best Sc score
>(YBR111c; protein ecoded by EMBL/GenBank Accession Number Z35980) and
>the mutT is shown below.  Nothing worth writing home about, although
>some domains may be conserved.  The dot plot between these two
>sequences shows that something may be there as well. 

YBR111c has recently been named YSA1 and reported as an ADP-ribose hydrolase 
by Bessman et al. JBC 271: 25059 1996. Interesting, since, as far as I know, 
there is no ADP-ribosylation in S.c. Maybe involved in NAD/H degradation 
pathway?

Preston Garrison, Ph.D.
Research Instructor
garrisonp at uthscsa.edu
Biochem. Dept.
Univ of Texas Health Sci Ctr
San Antonio, Tx 78284-7760 USA
210-567-3702



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