yeast GPI proteins & endocytosis

[rtemple at NETMAIL.HSCBKLYN.EDU]

Hello out there -

I am hoping that someone on this list works on yeast GPI proteins and/or endocytosis in yeast. I work w/ a human GPI protein & have a few simplistic questions...conjecture is welcome in the replies!

1) Will yeast endocytose cell surface GPI proteins? Do they have the right 'machinery' to do so?

2) I know that the signal sequences required for yeast GPI attachment have been studied. How homologous are these sites to humam/mouse/hamster GPI signal sequences?

Please feel free to contact me directly or respond on the list. Any pointers to articles that I have missed due to insufficient caffeine levels would be greatly appreciated. Thanks!

Robyn

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Robyn Temple, graduate student
SUNY Health Science Center at Brooklyn
rtemple at netmail.hscbklyn.edu
718-270-2933

450 Clarkson Avenue - Box 44
Department of Microbiology & Immunology
Brooklyn NY 11203