meaning of 'synthetic lethality'
mlamphier at hotmail.com
mlamphier at hotmail.com
Wed Apr 29 14:32:36 EST 1998
I have come across a term in yeast genetics I am
unfamiliar with. In a paper I am looking at the
researchers investigate combinations of mutations
for "synthetic lethality". This term seems to mean
simply that each individual mutation is non-lethal
but the two combined are lethal. Is this a correct
understanding, and what is the meaning of
"synthetic" here?
e.g. from paper: "...we have found synthetic-
lethality when the srt1 mutant allele was placed
in combination with a g-tubulin mutant allele..."
Marc Lamphier
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