Disruption an essencial gene in diploid yeast

Kara Dolinski kara at genome.Stanford.EDU
Tue Apr 4 16:10:06 EST 2000


Hi Yiling, 

Your gene might be haploinsufficent. There's a few examples of this--I did
a search for haploinsufficiency and Saccharomyces at Medline.  Here's an
example of a reference describing a gene that exhibits haploinsufficency:

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10468586&dopt=Abstract

Best wishes,
Kara
*****************************************************
 Kara Dolinski, Ph.D., Database Curator
 Saccharomyces Genome Database
 Stanford University Med. Ctr.
 Department of Genetics
 Stanford, CA 94305-5120 USA
 phone: (650)725-8956  fax: (650)723-7016
 e-mail:   yeast-curator at genome.stanford.edu
 WWW:   http://genome-www.stanford.edu/
*****************************************************



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