postdoc and PhD positions

Saskia M.van der Vies vdvies at chem.vu.nl
Thu Jul 6 08:42:14 EST 2000


2 Postdoctoral fellowships and 1 Ph.D. studentship

Ribosome Biogenesis and Stress Response

The Department of Biochemistry and Molecular Biology (Faculty of Science)
of the "Vrije Universiteit" in Amsterdam offers an outstanding environment
for research on Ribosome Biogenesis, Protein Folding and Stress Response.
The research programme is embedded in the Institute for Biomolecular
Sciences and the Research School BioCentrum Amsterdam. The department has
two three-year postdoctoral positions and one PhD studentship available
immediately. Funding for the projects is provided by the National Science
Foundation (N.W.O. / CW).


Ribosome Biogenesis

Postdoctoral Position  (3 years)
Ph.D. position  (4 years)

The projects are part of a research programme aimed at the identification
and characterisation of trans-acting factors involved in the processing of
pre-rRNA to the mature 5.8S, 18S and 25S rRNAs in the yeast Saccharomyces
cerevisiae.
The post-doctoral study is aimed at the elucidation of the role of Rrp5p,
so far the only trans-acting factor required for both 5.8S and 18S rRNA
production, using a combination of classical genetics, molecular genetics
and biochemical techniques.
The Ph.D. project concerns the role of Prp9p, a new component of the U3
snoRNP, a protein complex essentyial at the early stages of pre-RNA
processing. A detailed description of the project is available upon request.
Please contact Prof. H.A. Raué by email (raue at chem.vu.nl) or telephone
(+31-(0)20-4447545) or Dr. J.C. Vos (vos at chem.vu.nl; +31-(0)20-444 7559)
for further information.


Stress Response and Molecular Chaperones

Postdoctoral Position (3 years)

The project is part of a research programme that concerns the molecular
mechanism of protein folding and maintenance of protein structures inside
the living cell under physiological as well as stress-induced conditions.
Ongoing projects in the group are (i) the molecular mechanism by which the
GroEL/Gp31 molecular chaperone complex assists the folding of the
bacteriophage T4 capsid protein in Escherichia coli; (ii) the function of
the Hsp70 molecular chaperone in the cytosol of the yeast Saccharoymces
cerevisiae and (iii) the activation mechanism of the High Osmolarity
Glycerol (HOG) signalling pathway upon exposure of yeast cells to (extreme)
external osmolarity.
This project conderns the role of molecular chaperones in high osmolarity
signalling in the yeast Saccharoymces cerevisiae.
Please contact Prof. Saskia M. van der Vies by email (vdvies at chem.vu.nl) or
telephone (+31 (0)20 4447548) or Dr. Pim H. Mager (mager at chem.vu.nl; +31
(0)20 4447569) for an informal discussion.


Successful candidates should have a PhD in Molecular Biology, Biochemistry
or Genetics, practical experience with all major modern molecular
biological techniques and published in high impact molecular/biochemical
journals. Knowledge of yeast genetic and physiology is a distinct
advantage. The Postdoctoral candidate is expected to work independently and
to have good supervisory and communication skills.

The Vrije Universiteit (VU) is a medium size, modern and actively growing
university with 15 000 students and more than 2000 scientific staff
members. The university is situated in the lively and cosmopolitan are
The Faculty of Sciences supports a variety of research programmes in
(Bio)-Physics, (Bio and Pharmaco)-Chemistry, Mathematics and
(Bio)-Informatics. Undergraduate programmes in Physics, Informatics,
Mathematics, Artificial Intelligence in Physics, Informatics, Mathematics,
Artificial Intelligence, Pharmaceutical Sciences, Chemistry and Medical
Life Sciences and more than thirty specialised graduate programmes are
available. For general information please visit <www.few.nl> and
<www.chem.vu.nl>.


Applications, stating clearly which position you are applying for, should
include a detailed CV, publication list, a covering letter and names of 3
referees. Applications should be send to Drs. M. Peirera, Head of Personnel
Department, Faculty of Sciences, de Boelelaan 1083, 1081 HV Amsterdam.

_._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._.
Dr. Saskia M. van der Vies
Professor of  Biochemistry
Head of Department of Biochemistry and Molecular Biology
Faculty of Science
Vrije Universiteit
De Boelelaan 1083
1081 HV Amsterdam
The Netherlands

Phone:	+ 31 20 4447548 (office)
	+ 31 20 4447555 (secretary)
FAX:	+ 31 20 4447553
email:	vdvies at chem.vu.nl
_._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._._.V 



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