Postdoctoral Position in Signal Transduction

Katherine Borkovich Katherine.Borkovich at ucr.edu
Mon Nov 8 14:55:55 EST 2004


Postdoctoral Research Positions are available to study heterotrimeric
G protein and two-component regulatory system signaling pathways in
the eukaryotic filamentous fungus Neurospora crassa.  The complete
genome sequence is available for this organism (Galagan, Calvo and
Borkovich, et al., Nature 422: 859-868, 2003; Borkovich, Alex and
Yarden, et al., Microbiol. Mol. Biol. Rev. 68: 1-108, 2004) and
genome-wide approaches are underway, including high-throughput gene
deletions, gene annotation and transcriptional profiling analysis.
Neurospora is an ideal model system for G protein-effector
interactions in mammals and for G protein-mediated virulence in animal
and plant fungal pathogens.  Our laboratory has demonstrated that G
proteins and G protein coupled receptors (GPCRs) regulate growth and
differentiation in Neurospora through both cAMP-dependent and
independent pathways (e.g., Kays and Borkovich, Genetics 166:
1229-1240; Kim and Borkovich, Mol. Microbiol. 52: 1781-1798).
 Possible projects include identification of novel effectors,
determination of the relative contributions of multiple G
proteins and GPCRs to the regulatory networks, and
structure-function studies of a G protein subunits.  We have
recently initiated a project in the area of two-component
signaling in Neurospora.  Possible projects include mutation
and analysis of histidine kinase and response regulator genes,
as well as identification of downstream effector pathways. 
Applicants should have a Ph.D. degree in Biochemistry, Biology
or a related discipline, have recombinant DNA experience and
possess a good command of spoken and written English. 
Experience in microbiological techniques and protein
biochemistry is desirable.  Send a curriculum vitae (including
a list of publications) and the names of three references to
Dr. Katherine A. Borkovich, Associate Professor, Department of
Plant Pathology and Director, Graduate Program in Genetics,
Genomics and Bioinformatics, 900 University Avenue, University
of California, Riverside, CA 92521.  E-mail:
Katherine.Borkovich at ucr.edu.  FAX:  (951) 827-4294.  The
University of California, Riverside is an Equal Opportunity
Employer.  Women and Minorities are encouraged to apply.

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