[Yeast] Postdoc position evolutionary systems biology
(by clandry from post.harvard.edu)
Tue Apr 13 10:38:42 EST 2010
Applications are invited for a postdoctoral position in evolutionary systems
biology at the Laval University Institute for Integrative and Systems
Biology (IBIS)(Quebec, Canada) to study how natural genetic variation in the
budding yeast Saccharomyces cerevisiae affects evolutionarily and
ecologically important traits.
The successful candidate will study the genetic architecture, evolution and
robustness of signalling networks using the budding yeast and its close
relatives as models. The last decade has seen exponential growth in the
pace of DNA sequencing and revolutions in microscopy, computing, and
molecular visualization techniques. These advances have made it possible to
dissect the inner workings of cells as they respond to internal or external
cues. Despite the wealth of new data produced by these technologies, it
remains remarkably difficult to predict how mutations or recombination
affect complex physiological and morphological traits. Understanding how
genetic variation is converted into observable differences between organisms
is crucial for developing personalized medical treatments, bioengineering
cellular machines or fuels, and predicting the evolutionary potentials of
different alleles. Several levels of organization (gene expression, protein
localization, posttranslational modifications, protein-protein interactions)
will be studied in order to construct genotype-phenotype maps of complex
phenotypic responses. The project will be tailored according to the
This project is a collaboration involving Dr Scott Rifkin (University of
California San Diego, USA) and Dr Madan Babu (University of Cambridge, UK)
and is funded by the Human Frontier Science Program (HFSP).
Applicants must hold a PhD in biology or in a related discipline. The
candidate should have strong experience in molecular biology and preferably
also in microbiology. Experience with high throughput screening and
genotyping, statistics and yeast genetics would be an asset.
Université Laval is one of the first higher education institution in the
Americas and is one of the leading universities in Canada. Located in Quebec
City, a UNESCO world heritage city, Université Laval offers an outstanding
research and training environment for scholars.
Time of initial appointment: September 2010 (flexible).
Review of applications begins immediately and will continue until the
position is filled
Initial term of one year renewable for up to three years.
Competitive salary (40,000$+/year) depending on previous experience.
Interested candidates should contact Christian Landry
(clandry from post.harvard.edu) and include a cover letter describing research
interests, a CV and the names of two referees.
Visit our website for more details on our research
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