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Ed Goolish Ed_Goolish at QMGATE.ARC.NASA.GOV
Thu Dec 22 18:51:47 EST 1994


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        ANNOUNCEMENT!        ANNOUNCEMENT!       ANNOUNCEMENT!    
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          ARE YOU STUDYING THE DEVELOPMENTAL BIOLOGY OF ZEBRAFISH,
                      OR SOME OTHER AQUATIC MODEL?

   ________________________________________________________________
   WHAT ARE THE EFFECTS OF GRAVITY ON THE PARTICULAR ASPECT OF THEIR 
          DEVELOPMENTAL BIOLOGY WHICH YOU ARE STUDYING?
   ________________________________________________________________

     NASA IS DEVELOPING FACILITIES TO MAINTAIN AQUATIC ORGANISMS,
INCLUDING ZEBRAFISH, ON THE SPACE SHUTTLE AND/OR SPACE STATION TO
CONDUCT RESEARCH ON THE EFFECTS OF MICROGRAVITY ON THE DEVELOPMENTAL
BIOLOGY OF VERTEBRATES.

     IT IS ANTICIPATED THAT SHORT-TERM (HOURS TO DAYS) THRU LONG-TERM,
            MULTI-GENERATIONAL (>6 MONTHS) STUDIES WILL BE POSSIBLE. 

    THIS AMBITIOUS EFFORT, A PART OF THE GRAVITATIONAL BIOLOGY FACILITY
PROJECT, IS SOLICITING INPUT FROM MEMBERS OF THE SCIENTIFIC COMMUNITY
WHICH MAY BE USERS OF THE FACILITY ONCE IT IS OPERATIONAL.  SUGGESTIONS
ON THE KINDS OF EXPERIMENTS WHICH WOULD MAKE BEST USE OF THE FACILITY
WILL BE USED TO DEFINE WHAT THE SYSTEM WILL LOOK LIKE AND WHAT
CAPABILITIES IT WILL HAVE.

*  WHAT STAGES OF ZEBRAFISH DEVELOPMENT ARE MOST IMPORTANT TO YOU?
*  BY WHAT MECHANISMS DO YOU THINK GRAVITY AFFECTS DEVELOPMENT?
*  CAN YOU OBTAIN INFORMATION FROM MULTI-GENERATIONAL STUDIES?
*  HOW DO YOUR SAMPLES NEED TO BE FIXED?
*  WOULD OTHER SPECIES BE BETTER TO ADDRESS YOUR EXPERIEMNTAL OBJECTIVES?

     IF YOU ARE INTERESTED IN GIVING YOUR OPINIONS ON THESE AND OTHER ISSUES,
PLEASE RESPOND TO THE E-MAIL ADDRESS BELOW AND INCLUDE YOUR NAME, MAIL
ADDRESS, AND TELEPHONE/FAX NUMBERS;  OR CALL ME AT (415) 604-1961. 

   I WILL SEND YOU MORE INFORMATION ABOUT THE GRAVITATIONAL BIOLOGY FACILITY
PROJECT (GBF), AND A SHORT FORM FOR OUTLINING PARTICULAR EXPERIMENTS WHICH YOU
WOULD LIKE TO SEE DONE IN SPACE ON THE GBF. THESE REFERENCE EXPERIEMNTS WILL
BE USED TO HELP DESIGN THE AQUATIC HABITAT.

            IF YOU USE MEDAKA AS A MODEL SYSTEM,
                   WE WOULD LIKE TO HEAR FROM YOU TOO!

  WE ARE DEFINING DEVELOPMENTAL BIOLOGY VERY BROADLY, SO IF YOU HAVE CREATIVE
THOUGHTS ON HOW THE AQUATIC HABITAT COULD BE USED TO STUDY OTHER ASPECTS OF
GRAVITATIONAL BIOLOGY AMONG AQUATIC ORGANISMS, SUCH AS ORIENTATION/VESTIBULAR
OR CARDIOVASCULAR FUNCTION, PLEASE RESPOND WITH THOSE IDEAS AS WELL.

             CHEERS!
                                EDWARD M. GOOLISH
                                NASA AMES RESEARCH CENTER
                                P.O. BOX 138
                                MOFFETT FIELD, CA 94035

                                Tel:   415/604-1961
                                FAX:   415/604-1701
                                e-mail:  Ed_Goolish at qmgate.arc.nasa.gov





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