SBIR contract proposal due November 5, 1999

Deborah Deborah
Thu Sep 30 12:13:08 EST 1999


Small Business
Innovation Research Program 

Contract Proposal Receipt Date November 5, 1999

for more info see:
http://deainfo.nci.nih.gov/sbircontract/index.htm

The NIDA genetics workgroup is particularly interested in
proposals on:

24
 Web-based Visualization and Analysis of DNA
Micro-Array Data 
DNA micro-arrays are now available for simultaneous
measurement of the level of expression of thousands  of
genes. The Basic Neurobiology and Biological Systems
Research Branch, of the Division of Basic
Research, NIDA, is seeking proposals for development of a
web-based system for data visualization and analysis of
micro-array experiments with particular emphasis on
candidate genes and SNPs thought to be
involved in addiction vulnerability. The system must be
programmed in JAVA and be useable by experimental and
computational biologists with a web browser interface.
Visualization tools implemented
should include scatter-plot matrices, rotating point clouds,
3-d surface plots, dot plots of gene expression for multiple
experiments, parallel coordinate displays and image plots.
The set of genes shown on the plots should be dynamically
selectable using sliders for the intensity levels, and genome
locations. Clicking on a  point or set of points in a display
should result in the generation of a report identifying the
selected points as well as highlighting the corresponding
points in other displays. Information in other genomic
databases (e.g., Entrez) on points selected in displays should
be obtainable by point click. The system should interface
transparently to relational databases such as Sybase
containing the micro-array data. Successful applicants will
work with the Basic Neurobiology and Biological Systems
Research Branch and its collaborators to develop
specifications of software that can be utilized by
micro-array laboratories as prototypes for the development
of widely distributed products. The development of software
and algorithms that model the interaction among the
changes in gene expression such as epistasis is highly
encouraged. 

               Phase I would be used to demonstrate the
technical merit, feasibility, and scientific usefulness of the
project. In Phase II it is expected that a prototype be
completed and the methodology to visualize and analyze
data  be both reliable and valid.

      025
               Kits for DNA Micro-array Technology 
               DNA micro-assay technology is a powerful tool
for analyzing levels of expression of thousands of genes and
SNPs potentially involved in vulnerability to addiction. The
current limitation of this technology is the lack of
standardized kits that would permit individual laboratories to
make their own set of DNA chips andDNA microarrays.
The Basic Neurobiology and Biological Systems Research
Branch, of the Division of Basic Research, NIDA, is
seeking proposals for development of DNA micro-array kits
in which individual labs could make their own customized
DNA chips and arrays at low cost.Small Business
Innovation Research Program 

Contract Proposal Receipt Date November 5, 1999

for more info see:
http://deainfo.nci.nih.gov/sbircontract/index.htm

The NIDA genetics workgroup is particularly interested in
proposals on:

24
 Web-based Visualization and Analysis of DNA
Micro-Array Data 
DNA micro-arrays are now available for simultaneous
measurement of the level of expression of thousands  of
genes. The Basic Neurobiology and Biological Systems
Research Branch, of the Division of Basic
Research, NIDA, is seeking proposals for development of a
web-based system for data visualization and analysis of
micro-array experiments with particular emphasis on
candidate genes and SNPs thought to be
involved in addiction vulnerability. The system must be
programmed in JAVA and be useable by experimental and
computational biologists with a web browser interface.
Visualization tools implemented
should include scatter-plot matrices, rotating point clouds,
3-d surface plots, dot plots of gene expression for multiple
experiments, parallel coordinate displays and image plots.
The set of genes shown on the plots should be dynamically
selectable using sliders for the intensity levels, and genome
locations. Clicking on a  point or set of points in a display
should result in the generation of a report identifying the
selected points as well as highlighting the corresponding
points in other displays. Information in other genomic
databases (e.g., Entrez) on points selected in displays should
be obtainable by point click. The system should interface
transparently to relational databases such as Sybase
containing the micro-array data. Successful applicants will
work with the Basic Neurobiology and Biological Systems
Research Branch and its collaborators to develop
specifications of software that can be utilized by
micro-array laboratories as prototypes for the development
of widely distributed products. The development of software
and algorithms that model the interaction among the
changes in gene expression such as epistasis is highly
encouraged. 

               Phase I would be used to demonstrate the
technical merit, feasibility, and scientific usefulness of the
project. In Phase II it is expected that a prototype be
completed and the methodology to visualize and analyze
data  be both reliable and valid.

      025
               Kits for DNA Micro-array Technology 
               DNA micro-assay technology is a powerful tool
for analyzing levels of expression of thousands of genes and
SNPs potentially involved in vulnerability to addiction. The
current limitation of this technology is the lack of
standardized kits that would permit individual laboratories to
make their own set of DNA chips andDNA microarrays.
The Basic Neurobiology and Biological Systems Research
Branch, of the Division of Basic Research, NIDA, is
seeking proposals for development of DNA micro-array kits
in which individual labs could make their own customized
DNA chips and arrays at low cost.




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