graduate student position available

Jeroen den Hertog hertog at
Wed Mar 28 11:30:58 EST 2001

Position available:		Graduate student
Project title:			Phosphotyrosine in development
Principal investigator:	Jeroen den Hertog
Starting date:			As soon as possible
Duration: 			Four years

Requirements:	University degree (M.Sc. or comparable) in biology 
or biochemistry; affinity for developmental biology

Description of the project

Protein phosphorylation on tyrosine residues is one of the most 
important cell signalling mechanisms that plays a pivotal role in 
cell proliferation, differentiation, migration and transformation. 
Cellular protein phosphotyrosine (p.Tyr) levels are regulated by the 
antagonistic activities of the protein-tyrosine kinases (PTKs) and 
protein-tyrosine phosphatases (PTPs), two large families of 
enzymes. It is evident that some PTKs as well as PTPs are 
essential for normal embryonic development. Still, relatively little is 
known about which tyrosine phosphorylation events are crucial.  

The aim of this project is to obtain insight into the role of tyrosine 
(de)phosphorylation in vertebrate embryonic development by 
analysis of tyrosine (de)phosphorylation in developing zebrafish 

Interested?	 Please send applications with CV to:
Dr. J. den Hertog, e-mail: hertog at

Hubrecht Laboratory 
Netherlands Institute for Developmental Biology
Uppsalalaan 8
3584 CT Utrecht 
The Netherlands

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