thymidine kinase cell lineage ablation technique

Allen R. Place place at
Fri May 25 14:32:23 EST 2001

I'm interested if anybody has tried the thymidine kinase cell lineage 
ablation technique with zebrafish?  If so how successful was it? 
Also a side question is whether anyone knows if zebrafish larvae 
are sensitive to antiherpetic drug ganciclovir (GCV)? This method is 
based on the selective toxicity to GCV in cells expressing a herpes 
virus thymidine kinase suicide gene.  I hope you can help Al  

Allen R. Place, Associate Professor     email:place at
Center of Marine Biotechnology          voice:       410-234-8828
Columbus Center, Suite 236              Personal Fax:410-468-3909 
East Pratt Street			Center Fax:  410-234-8896 Baltimore, 
MD 21202 USA

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