JOB VACANCY

[Lucy Byrnes]

POSTDOCTORAL POSITION

The developmental role of the IGF-1 receptor in vertebrates, using 
zebrafish as a model species.  

Recently, the DeRobertis group (Pera et al., 2001) discovered that 
IGF signals are both required and sufficient for anterior neural and 
head induction in Xenopus. This function of the IGFs was not 
apparent from mouse knock-out studies and it is not clear how 
widespread it is in vertebrates. Zebrafish is a better model species 
for studies of vertebrate developmental, due to its well-understood 
embryology and genetics, and we have cloned the complete cDNA 
for the zebrafish IGF-1 receptor (Ayaso et al., 2002). The aim of 
this project is to use both 'loss-of-function' and 'gain-of-function' 
approaches to examine the developmental role of the IGF-1 
receptor in zebrafish. This is a collaborative project with Dr. Kay 
Nolan, Zoology Department, University College Dublin.  

Suitable candidates will have an interest in the molecular biology of 
development with experience in either cell or molecular biology. 
The ideal candidate would also have experience of microinjection 
techniques.  

The position is available for up to 3 years and the salary will be 
commensurate with experience.  

For further information, contact:
Dr. Lucy Byrnes
Department of Biochemistry
National University of Ireland
Galway
Phone: +353-91-524411 ext.2416
Email:  Lucy.Byrnes at nuigalway.ie

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Dr. Lucy Byrnes
Department of Biochemistry
National University of Ireland
Galway
IRELAND
Ph: +353-91-524411 ext.2416
FAX: +353-91-525700
email: Lucy.Byrnes at nuigalway.ie
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