Job Ad

[Richard Dorsky]

Wnt/beta-catenin targets in the zebrafish CNS

A funded postdoctoral position is available at the University of Utah 
to study the role of Wnt/beta-catenin-mediated transcription in 
zebrafish CNS cell fate specification.  Available projects include 
loss-of-function analysis of Lef/Tcf genes during spinal cord 
development, overexpression studies of beta-catenin activators and 
inhibitors, and screens for target genes and mutations that affect 
signaling.  Several transgenic zebrafish lines are available for these 
experiments, including a beta-catenin transcriptional reporter (Dev 
Biol 241:229-237) and an inducible inhibitor of beta-catenin/Tcf 
signaling. The goal of this work is to identify target cells of beta-
catenin during CNS development, and the genes that control their 
fate decisions. Applicants should send CV and references to:  

       Dr. Richard Dorsky
       University of Utah
       Department of Neurobiology and Anatomy
       20 North 1900 East
       Salt Lake City, UT 84132-3401
       Phone (801) 581-6073
       Fax (801) 581-4233
       Email: richard.dorsky at hsc.utah.edu