Postdoctoral Investigator, Woods Hole

Mark E. Hahn mhahn at
Mon Dec 15 10:43:41 EST 2003

Postdoctoral Investigator Position
Biology Department
Woods Hole Oceanographic Institution
Woods Hole, MA  U.S.A.

I am seeking a postdoctoral investigator to participate in NIH-funded 
research to examine the function of the aryl hydrocarbon receptor 
(AHR) signaling pathway and its role in vertebrate development and in 
the developmental toxicity of chlorinated dioxins and related chemicals.  
The research will involve one or more of the following approaches:  
promoter analysis using transgenic zebrafish, functional knock-down of 
gene expression in zebrafish, molecular cloning of AHR and other 
genes in Fugu and medaka, in situ hybridization, cell transfection, and 
functional genomic analyses in fish and in mammalian cells.  (See 
representative references listed below.) Molecular biology experience 
is essential.  Previous experience in one or more of the following is 
desirable: zebrafish developmental biology; microinjection of fish eggs; 
transgenic fish technologies; comparative or functional genomics; in 
situ hybridization, culture of mammalian cells.  

Start date:  As soon as possible, but no later than March 1, 2004. One 
year appointment, possible extension for up to 3 years. Salary: Starting 
at ~$45,300 per year, depending on previous experience.  

Education required:  Ph.D. in biochemistry, molecular biology, 
toxicology, developmental biology, genomics or related field.  Less 
than 4 years postdoctoral experience.  

For further information, contact:  Mark E. Hahn, Ph.D., Biology 
Department, Woods Hole Oceanographic Institution, Redfield 338; MS-
32, 45 Water Street, Woods Hole, MA  02543;  Phone 508-289-3242; 
Fax 508-457-2134; mhahn at  

To apply, go to

Representative publications:

Hahn, M.E. (2002) Aryl hydrocarbon receptors: Diversity and evolution. 
Chem.-Biol. Interact. 141: 131-160.  

Karchner, S.I., Franks, D.G., Powell, W.H., and Hahn, M.E. (2002) 
Regulatory interactions among three members of the vertebrate aryl 
hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. J. Biol. 
Chem. 277: 6949-6959.  

Karchner, S.I., Powell, W.H., and Hahn, M.E. (1999) Identification and 
functional characterization of two highly divergent aryl hydrocarbon 
receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. 
Evidence for a novel subfamily of ligand-binding basic helix-loop-helix 
Per-ARNT-Sim (bHLH-PAS) factors. J. Biol. Chem. 274: 33814-33824.  

Hahn, M.E., Karchner, S.I., Shapiro, M.A., and Perera, S.A. (1997) 
Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) 
receptors (AHR1 and AHR2) and the PAS family. Proc. Natl. Acad. Sci. 
U.S.A. 94: 13743-13748.  

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