Postdoctoral Investigator, Woods Hole

Mark E.Hahn mhahn at
Thu Dec 16 08:06:00 EST 2004


Postdoctoral Investigator
Biology Department
Woods Hole Oceanographic Institution
Woods Hole, MA  U.S.A.

Postdoctoral investigator position available to participate in
NIH-funded research to examine the function of the aryl hydrocarbon 
receptor (AHR) signaling pathway (including AHR1, AHR2, and AHR
Repressor) and its role in vertebrate development and in the
developmental toxicity of chlorinated dioxins and related chemicals.   The
research will involve a combination of the following approaches:  in  vivo
promoter analysis and functional knock-down of gene expression in 
zebrafish embryos, molecular cloning of AHR pathway genes in zebrafish, 
Fugu, and medaka, phylogenetic analysis and comparative genomics, in  situ
hybridization, cell transfection, and functional genomic analyses  in fish
and in mammalian cells.  Results will be interpreted within the  context
of the evolutionary relationships among the genes and species  under
study.  (See representative publications listed below.) Molecular  biology
experience is essential.  Previous experience in one or more of  the
following is desirable: zebrafish developmental biology;
microinjection of fish eggs; transgenic fish technologies; comparative  or
functional genomics; in situ hybridization; microscopy; mammalian  cell

Start date:  As soon as possible, but position will remain open until 
filled.  One year appointment, possible extension for up to 3 years. 
Salary:  Starting at ~$47,320 per year, depending on previous experience.

Education required:  M.D. or Ph.D. in biochemistry, molecular biology, 
toxicology, developmental biology, genomics or related field.  Less than 
4 years postdoctoral experience.

For further information, contact:  Mark E. Hahn, Ph.D., Biology
Department, Woods Hole Oceanographic Institution, Redfield 338;  MS-32, 
45 Water Street, Woods Hole, MA  02543;  Phone 508-289-3242; Fax
508-457-2134; mhahn at

To apply, go to  (Announcement Number  04-11-05)

Representative publications (reprints available upon request):

Hahn, M.E. (2002) Aryl hydrocarbon receptors: Diversity and evolution. 
Chem.-Biol. Interact. 141: 131-160.

Karchner, S.I., Franks, D.G., Powell, W.H., and Hahn, M.E. (2002) 
Regulatory interactions among three members of the vertebrate aryl 
hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. J. Biol. 
Chem. 277: 6949-6959.

Karchner, S.I., Powell, W.H., and Hahn, M.E. (1999) Identification and 
functional characterization of two highly divergent aryl hydrocarbon 
receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus.
Evidence for a novel subfamily of ligand-binding basic helix-loop-helix 
Per-ARNT-Sim (bHLH-PAS) factors. J. Biol. Chem. 274: 33814-33824.

Hahn, M.E., Karchner, S.I., Shapiro, M.A., and Perera, S.A. (1997) 
Molecular evolution of two vertebrate aryl hydrocarbon (dioxin)
receptors (AHR1 and AHR2) and the PAS family. Proc. Natl. Acad. Sci. 
U.S.A. 94: 13743-13748.


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