ZF Blood-Brain-Barrier

Donald O'Malley d.omalley at neu.edu
Wed Jan 28 11:18:24 EST 2004

Hi Folks,

Does anyone know of information regarding the development of the 
blood-brain barrier in zebrafish?  We are specifically interested in its 
permeability at larval stages.  Any citations or anecdotal experience 
about what compounds get into the CNS at the 5 to 10 day PF stage 
would be welcome. [i.e. with bath application].   

Obviously MS222 does and I know that caffeine permeates larvae 
pretty quickly, but I don't know much more than that!  


Donald M. O'Malley
Associate Professor 
Dept. Biology
Northeastern University
d.omalley at neu.edu

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