[Zbrafish] EMBO Course Endocytosis and signalling
brand at mpi-cbg.de
Wed Jul 6 02:55:57 EST 2005
please take note of the following
EMBO practical course "Endocytosis and signaling during development"
that we organize in Dresden, and for which we currently invite
Application deadline is July 14 th, 2005.
EMBO Practical Course on
Endocytosis and signaling during development
Dresden, October 4-15, 2005
Organizers: Marcos Gonzalez-Gaitan, Michael Brand, Marino Zerial
Hands-on practical course on the following topics
- imaging endocytic trafficking in developing flies and fish
- receptor ubiquitination/endocytosis in culture cells
- endocytic assays during asymmetric cell division
- mathematical modelling of endocytic trafficking
- endocytic assays in culture cells
- FRAP, photoactivation
- electron microscopy
Further information, application forms etc.:
Application deadline: July 14 th, 2005.
Major objectives of the course:
i) to teach the participants the state of the art, emerging techniques
to study endocytosis during signaling events in development of fish and
ii) to teach the participants high-resolution cell biological
techniques as applied to vertebrate cell culture in the endocytosis
field to expand the traditionally high standards of classical
molecular cell biology to the tissue level.
The study of signaling during tissue development is leaving behind a
phase where formal genetic models account for the observed phenomena
and enters a period where cell-to-cell communication is understood at
the level of cell biology. In this trend, endocytosis and its
interphase with cell signaling are in sharp focuses. Beyond the
down-regulation of receptors by internalization, new roles for
endocytosis during signaling include
i) the secretion of ligands through exosomes,
ii) regulating the spread of morphogens through endocytosis and
iii) the compartmentalisation of signal transduction events in
iv) the generation of directional signaling during asymmetric cell
division, among others.
These developments concern mainly two model organisms: fish and flies.
These genetic model organisms have proven particularly useful in
studying the role of endocytosis during development, because they allow
rigorous genetic dissection, high-resolution imaging and manipulation
of the cells machinery in relation to well-understood morphogenetic
signaling events in the embryo or imaginal discs.
The course will be aimed at Ph.D. students and young Post-docs, who
have decided to enter the emerging interface between the fields of Cell
Biology and Development, and therefore need to become acquainted with
some of the specific methods and tools that fish and flies offer to
follow completely new experimental avenues.
Pier Paolo di Fiore
Jean Paul Vincent
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