[Zbrafish] Post-doctoral positions - Institut Pasteur

Estelle Hirsinger via zbrafish%40net.bio.net (by e.hirsinger from gmail.com)
Wed Dec 8 12:35:43 EST 2010

Elongation in mouse and zebrafish: in vivo and in silico analyses of
cell behaviours

Two positions for enthusiastic scientists (post-doctoral fellows or
researchers holding a permanent position) are available in the
laboratory of JF. Nicolas in the Department of Developmental Biology,
Institut Pasteur, Paris, France. The equivalent of 2-year post-
doctoral funding, available between January 2011 and December 2013, is
provided by an ANR grant.

The research projects focus on embryo elongation in zebrafish and
mouse and the relative contributions of distinct cell behaviours (cell
rearrangements, division orientation and modes of growth of precursor
pools) to this process. They involve two large-scale approaches, in
vivo retrospective clonal analysis and 4D imaging and in silico cell
tracking. We propose to understand whether the embryo uses distinct
cell-based developmental modules to elongate during successive
developmental phases that are heterogeneous in modalities. The
comparison of this study with that conducted in the laboratory in
amphioxus should allow us to develop an evolutionary perspective on
embryo elongation.
The Developmental Biology department at Institut Pasteur provides a
highly stimulating and interactive scientific environment, state of
the art facilities dedicated to imaging and image analysis, genomics
and proteomics and an active programme of seminars (http://

Candidates holding a PhD with a strong background in Molecular Biology
and Developmental Biology are encouraged to apply. Experience in
zebrafish or mouse genetics is preferred but not required.

Candidates interested in this position should send a covering letter
stating why they are interested in the position, a full CV with
bibliography and details of at least two referees to Dr. E. Hirsinger
and Pr. JF. Nicolas at the addresses below. Only short-listed
applicants will be contacted. Interviews will take place in January

Institut Pasteur, Département de Biologie Moléculaire du
Développement, 25 rue du Docteur Roux, 75724 Paris cedex 15, France, e-
mails : estelle.hirsinger from pasteur.fr; jean-
francois.nicolas from pasteur.fr.

Recent/related publications :
 Dolez M., Nicolas JF. and Hirsinger E. (2011). Development, 138:
 Legué E., Sequeira I. and Nicolas J.F. (2010). Development, 137:
 Tzouanacou E., Wegener A., Wymeersch F.J.A., Wilson V. and Nicolas,
JF. (2009). Dev. Cell, 17:365-376.

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