<html><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><!--StartFragment--><p class="MsoNormal" style="text-align:justify"><font class="Apple-style-span" face="Arial">
<!--StartFragment--><p class="MsoNormal" style="text-align:justify"><span style="">To
the Members of the Zebrafish Community:</span></p><p class="MsoNormal" style="text-align:justify"><span style="">The
Zebrafish TILLING Consortium is pleased to announce the launch of a submission
site for TILLING requests. <a href="http://en.wikipedia.org/wiki/Tilling_(molecular_biology)">TILLING</a> is
a method for finding unique ENU-induced mutations in specific genes in a library of mutagenized fish. This project is a joint effort of the Moens lab at the
Fred Hutchinson Cancer Research Center, the Solnica-Krezel lab at Vanderbilt
University, and the Postlethwait lab at the University of Oregon. The goal of
the project is to generate and distribute loss-of-function mutations in genes
of interest to the zebrafish community. Our labs have established large
cryopreserved libraries of ENU-mutagenized zebrafish and have identified
loss-of-function mutations in over 70 zebrafish genes to date. Our
consortium-based approach will be to screen genes of interest sequentially at
the three locations. This work is supported by a multi-PI NIH Grant
HG002995-04, which provides salary support for TILLING personnel. The cost of
TILLING consumables is passed on to the requesters.</span></p><p class="MsoNormal" style="text-align:justify"><span style="">To
learn more about the project and to submit your requests online, go to:<o:p></o:p></span></p><p class="MsoNormal" style="text-align:justify"><span style="font-size: 10pt; color: rgb(0, 11, 255); "><a href="http://www.fhcrc.org/tilling"><span style="font-size:12.0pt;mso-bidi-font-size:
10.0pt;mso-bidi-font-family:"Times New Roman""><o:p></o:p></span></a></span></p><p class="MsoNormal" style="text-align:justify"><span class="MsoHyperlink"><span style="font-size: 10pt; "><a href="http://www.fhcrc.org/tilling">http://www.fhcrc.org/tilling</a></span></span></p><p class="MsoNormal" style="text-align:justify"><span style="">Yours
truly,</span></p><p class="MsoNormal" style="text-align:justify"><span style="">Cecilia
Moens, Lila Solnica-Krezel and John Postlethwait.</span></p></font></p><div apple-content-edited="true"><font class="Apple-style-span" face="Arial"> </font></div><br></body></html>
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