foomevolUSENET GROUP NAME: bionet.molbio.recombination Status: Moderated One-line description: Research on the recombination of DNA or RNA Moderation address: recom@net.bio.net (recom-moderator@net.bio.net is an alias for recom@net.bio.net) Moderator: Graham Dellaire Proposed mailing list name: RECOMBINATION Proposed e-mail address: recom@net.bio.net Newsgroup Charter: The purpose of the RECOMBINATION newsgroup is to provide a proper forum for the discussion of issues pertaining and involving recombination of DNA or RNA, in its many forms (see Topics of Discussion). Primarily it should enable those researchers who work in recombination or aligned fields to communicate ideas and information, as well as, provide a chance for collaboration among national and international research groups. Topics of Discussion include: 1. Gene conversion and ectopic integration 2. Genome accessibility and nuclear/chromosome structure and recombination -Matrix attachment sites (MARS) -nucleosomes, histone 1 -recombination hotspots -fragile sites -origins of replication 3. Effect of DNA topology on recombination (Triple strand, Z-DNA, cruciform, bent etc) 4. Homologous recombination vs. nonhomologous or illegitimate -comparisons between bacterial, yeast and higher eukaryotic recombination systems (ex. fungi, mammals) 5. Models of recombination (One-end invasion, Double strand Break Repair, SSA etc) 6. Site-specific recombination systems (invertase, Cre and Flp recombinase etc) 7. Specific recombination systems in complex organisms -VDJ recombination -Antigenic variation and recombination (ex. trypanosomes, HIV, N.gonorrhea) -Yeast mating type locus 8. Transcription and recombination 9. DNA replication and recombination (ex. gene amplification (DHFR etc)) 10. Evolution of the Genome -retroposons (Line-1, Sine's), retroviruses and transposons -formation of gene clusters and comparative mapping -recombination between other repeat elements (alpha satellites, telomeres) 11. DNA repair systems and recombination (DSB and mismatch repair) -including DNA repair deficient diseases (ex. Xoderma Pigmentosum) 12. Applications of recombination -Gene therapy -Transgenics and gene transfer 13. Viral diversity through RNA recombination 14. Population genetics and recombination:i.e. as a source of allelic variation and as a measure of genetic exchange within and between populations. In addition this newsgroup provides: A forum for the exchange of information about future congresses and meetings in areas of molecular biology relating to recombination A forum for the exchange of information about textbooks, internet resources, visual materials, and computer programs. A source of quick help for last-minute troubleshooting, sources of materials, and practical advice; in areas such as -Vector design for transgene experiments -Gene transfer techniques -Animal models and cell lines -Gene therapy protocols Subscribers are welcome. Contributions within the functions outlined above are encouraged. Moderation Policy: Mass-posted commercial messages, chain letters, and similar postings not germane to plants or signal transduction will be deleted without comment. Inappropriate messages posted in good faith will be returned to the sender. Messages not strictly within the charter but likely to be of interest to many subscribers (e.g., job openings in the recombination field) ) will be accepted. Use of the newsgroup for commercial purposes is prohibited. Graham Dellaire email: dellaire@odyssee.net Div. of Experimental Medicine Fax: 1+ (514) 896 4689 McGill University Tel: 1+ (514) 281 6000 ext. 6936 Snail Mail: Institut du cancer de Montreal 1560 Sherbrooke St. East Montreal, Quebec, CANADA H2L 4M1